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All-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis
Electroretinogram examinations serve as routine clinical procedures in ophthalmology for the diagnosis and management of many ocular diseases. However, the rigid form factor of current corneal sensors produces a mismatch with the soft, curvilinear, and exceptionally sensitive human cornea, which typ...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943761/ https://www.ncbi.nlm.nih.gov/pubmed/33750806 http://dx.doi.org/10.1038/s41467-021-21916-8 |
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author | Kim, Kyunghun Kim, Ho Joong Zhang, Haozhe Park, Woohyun Meyer, Dawn Kim, Min Ku Kim, Bongjoong Park, Heun Xu, Baoxing Kollbaum, Pete Boudouris, Bryan W. Lee, Chi Hwan |
author_facet | Kim, Kyunghun Kim, Ho Joong Zhang, Haozhe Park, Woohyun Meyer, Dawn Kim, Min Ku Kim, Bongjoong Park, Heun Xu, Baoxing Kollbaum, Pete Boudouris, Bryan W. Lee, Chi Hwan |
author_sort | Kim, Kyunghun |
collection | PubMed |
description | Electroretinogram examinations serve as routine clinical procedures in ophthalmology for the diagnosis and management of many ocular diseases. However, the rigid form factor of current corneal sensors produces a mismatch with the soft, curvilinear, and exceptionally sensitive human cornea, which typically requires the use of topical anesthesia and a speculum for pain management and safety. Here we report a design of an all-printed stretchable corneal sensor built on commercially-available disposable soft contact lenses that can intimately and non-invasively interface with the corneal surface of human eyes. The corneal sensor is integrated with soft contact lenses via an electrochemical anchoring mechanism in a seamless manner that ensures its mechanical and chemical reliability. Thus, the resulting device enables the high-fidelity recording of full-field electroretinogram signals in human eyes without the need of topical anesthesia or a speculum. The device, superior to clinical standards in terms of signal quality and comfortability, is expected to address unmet clinical needs in the field of ocular electrodiagnosis. |
format | Online Article Text |
id | pubmed-7943761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79437612021-03-28 All-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis Kim, Kyunghun Kim, Ho Joong Zhang, Haozhe Park, Woohyun Meyer, Dawn Kim, Min Ku Kim, Bongjoong Park, Heun Xu, Baoxing Kollbaum, Pete Boudouris, Bryan W. Lee, Chi Hwan Nat Commun Article Electroretinogram examinations serve as routine clinical procedures in ophthalmology for the diagnosis and management of many ocular diseases. However, the rigid form factor of current corneal sensors produces a mismatch with the soft, curvilinear, and exceptionally sensitive human cornea, which typically requires the use of topical anesthesia and a speculum for pain management and safety. Here we report a design of an all-printed stretchable corneal sensor built on commercially-available disposable soft contact lenses that can intimately and non-invasively interface with the corneal surface of human eyes. The corneal sensor is integrated with soft contact lenses via an electrochemical anchoring mechanism in a seamless manner that ensures its mechanical and chemical reliability. Thus, the resulting device enables the high-fidelity recording of full-field electroretinogram signals in human eyes without the need of topical anesthesia or a speculum. The device, superior to clinical standards in terms of signal quality and comfortability, is expected to address unmet clinical needs in the field of ocular electrodiagnosis. Nature Publishing Group UK 2021-03-09 /pmc/articles/PMC7943761/ /pubmed/33750806 http://dx.doi.org/10.1038/s41467-021-21916-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kim, Kyunghun Kim, Ho Joong Zhang, Haozhe Park, Woohyun Meyer, Dawn Kim, Min Ku Kim, Bongjoong Park, Heun Xu, Baoxing Kollbaum, Pete Boudouris, Bryan W. Lee, Chi Hwan All-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis |
title | All-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis |
title_full | All-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis |
title_fullStr | All-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis |
title_full_unstemmed | All-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis |
title_short | All-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis |
title_sort | all-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943761/ https://www.ncbi.nlm.nih.gov/pubmed/33750806 http://dx.doi.org/10.1038/s41467-021-21916-8 |
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