Cargando…

A Meta-Analysis of Risk Factors for Transient and Permanent Hypocalcemia After Total Thyroidectomy

BACKGROUND: As hypocalcemia is the most common complication of total thyroidectomy, identifying its risk factors should guide prevention and management. The purpose of this study was to determine the risk factors for postthyroidectomy hypocalcemia. METHODS: We searched PubMed, Web of Science and EMB...

Descripción completa

Detalles Bibliográficos
Autores principales: Qin, Yuan, Sun, Wei, Wang, Zhihong, Dong, Wenwu, He, Liang, Zhang, Ting, Zhang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943836/
https://www.ncbi.nlm.nih.gov/pubmed/33718114
http://dx.doi.org/10.3389/fonc.2020.614089
_version_ 1783662577070374912
author Qin, Yuan
Sun, Wei
Wang, Zhihong
Dong, Wenwu
He, Liang
Zhang, Ting
Zhang, Hao
author_facet Qin, Yuan
Sun, Wei
Wang, Zhihong
Dong, Wenwu
He, Liang
Zhang, Ting
Zhang, Hao
author_sort Qin, Yuan
collection PubMed
description BACKGROUND: As hypocalcemia is the most common complication of total thyroidectomy, identifying its risk factors should guide prevention and management. The purpose of this study was to determine the risk factors for postthyroidectomy hypocalcemia. METHODS: We searched PubMed, Web of Science and EMBASE through January 31, 2019, and assessed study quality using the Newcastle–Ottawa Scale. RESULTS: Fifty studies with 22,940 patients met the inclusion criteria, of which 24.92% (5716/22,940) had transient hypocalcemia and 1.96% (232/11,808) had permanent hypocalcemia. Significant (P < 0.05) predictors of transient hypocalcemia were: younger age, female, parathyroid autotransplantation (PA), inadvertent parathyroid excision (IPE), Graves’ disease (GD), thyroid cancer, central lymph node dissection, preoperative severe Vitamin D deficiency, preoperative Vitamin D deficiency and a lower postoperative 24 h parathyroid hormone (PTH) level. Preoperative magnesium, preoperative PTH and Hashimoto’s thyroiditis were not significant predictors of transient hypocalcemia. IPE, GD, and thyroid cancer were associated with an increased rate of permanent hypocalcemia, but gender and PA did not predict permanent hypocalcemia. CONCLUSION: Important risk factors for transient and permanent hypocalcemia were identified. However, given the limited sample size and heterogeneity of this meta-analysis, further studies are required to confirm our preliminary findings.
format Online
Article
Text
id pubmed-7943836
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-79438362021-03-11 A Meta-Analysis of Risk Factors for Transient and Permanent Hypocalcemia After Total Thyroidectomy Qin, Yuan Sun, Wei Wang, Zhihong Dong, Wenwu He, Liang Zhang, Ting Zhang, Hao Front Oncol Oncology BACKGROUND: As hypocalcemia is the most common complication of total thyroidectomy, identifying its risk factors should guide prevention and management. The purpose of this study was to determine the risk factors for postthyroidectomy hypocalcemia. METHODS: We searched PubMed, Web of Science and EMBASE through January 31, 2019, and assessed study quality using the Newcastle–Ottawa Scale. RESULTS: Fifty studies with 22,940 patients met the inclusion criteria, of which 24.92% (5716/22,940) had transient hypocalcemia and 1.96% (232/11,808) had permanent hypocalcemia. Significant (P < 0.05) predictors of transient hypocalcemia were: younger age, female, parathyroid autotransplantation (PA), inadvertent parathyroid excision (IPE), Graves’ disease (GD), thyroid cancer, central lymph node dissection, preoperative severe Vitamin D deficiency, preoperative Vitamin D deficiency and a lower postoperative 24 h parathyroid hormone (PTH) level. Preoperative magnesium, preoperative PTH and Hashimoto’s thyroiditis were not significant predictors of transient hypocalcemia. IPE, GD, and thyroid cancer were associated with an increased rate of permanent hypocalcemia, but gender and PA did not predict permanent hypocalcemia. CONCLUSION: Important risk factors for transient and permanent hypocalcemia were identified. However, given the limited sample size and heterogeneity of this meta-analysis, further studies are required to confirm our preliminary findings. Frontiers Media S.A. 2021-02-24 /pmc/articles/PMC7943836/ /pubmed/33718114 http://dx.doi.org/10.3389/fonc.2020.614089 Text en Copyright © 2021 Qin, Sun, Wang, Dong, He, Zhang and Zhang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Qin, Yuan
Sun, Wei
Wang, Zhihong
Dong, Wenwu
He, Liang
Zhang, Ting
Zhang, Hao
A Meta-Analysis of Risk Factors for Transient and Permanent Hypocalcemia After Total Thyroidectomy
title A Meta-Analysis of Risk Factors for Transient and Permanent Hypocalcemia After Total Thyroidectomy
title_full A Meta-Analysis of Risk Factors for Transient and Permanent Hypocalcemia After Total Thyroidectomy
title_fullStr A Meta-Analysis of Risk Factors for Transient and Permanent Hypocalcemia After Total Thyroidectomy
title_full_unstemmed A Meta-Analysis of Risk Factors for Transient and Permanent Hypocalcemia After Total Thyroidectomy
title_short A Meta-Analysis of Risk Factors for Transient and Permanent Hypocalcemia After Total Thyroidectomy
title_sort meta-analysis of risk factors for transient and permanent hypocalcemia after total thyroidectomy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943836/
https://www.ncbi.nlm.nih.gov/pubmed/33718114
http://dx.doi.org/10.3389/fonc.2020.614089
work_keys_str_mv AT qinyuan ametaanalysisofriskfactorsfortransientandpermanenthypocalcemiaaftertotalthyroidectomy
AT sunwei ametaanalysisofriskfactorsfortransientandpermanenthypocalcemiaaftertotalthyroidectomy
AT wangzhihong ametaanalysisofriskfactorsfortransientandpermanenthypocalcemiaaftertotalthyroidectomy
AT dongwenwu ametaanalysisofriskfactorsfortransientandpermanenthypocalcemiaaftertotalthyroidectomy
AT heliang ametaanalysisofriskfactorsfortransientandpermanenthypocalcemiaaftertotalthyroidectomy
AT zhangting ametaanalysisofriskfactorsfortransientandpermanenthypocalcemiaaftertotalthyroidectomy
AT zhanghao ametaanalysisofriskfactorsfortransientandpermanenthypocalcemiaaftertotalthyroidectomy
AT qinyuan metaanalysisofriskfactorsfortransientandpermanenthypocalcemiaaftertotalthyroidectomy
AT sunwei metaanalysisofriskfactorsfortransientandpermanenthypocalcemiaaftertotalthyroidectomy
AT wangzhihong metaanalysisofriskfactorsfortransientandpermanenthypocalcemiaaftertotalthyroidectomy
AT dongwenwu metaanalysisofriskfactorsfortransientandpermanenthypocalcemiaaftertotalthyroidectomy
AT heliang metaanalysisofriskfactorsfortransientandpermanenthypocalcemiaaftertotalthyroidectomy
AT zhangting metaanalysisofriskfactorsfortransientandpermanenthypocalcemiaaftertotalthyroidectomy
AT zhanghao metaanalysisofriskfactorsfortransientandpermanenthypocalcemiaaftertotalthyroidectomy