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The Role of Cold Inducible RNA-Binding Protein in Cardiac Physiology and Diseases

Cold-inducible RNA-binding protein (CIRP) is an intracellular stress-response protein that can respond to various stress conditions by changing its expression and regulating mRNA stability. As an RNA-binding protein, CIRP modulates gene expression at the post-transcriptional level, including those g...

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Autores principales: Zhong, Peng, Peng, Jianye, Bian, Zhouyan, Huang, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943917/
https://www.ncbi.nlm.nih.gov/pubmed/33716740
http://dx.doi.org/10.3389/fphar.2021.610792
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author Zhong, Peng
Peng, Jianye
Bian, Zhouyan
Huang, He
author_facet Zhong, Peng
Peng, Jianye
Bian, Zhouyan
Huang, He
author_sort Zhong, Peng
collection PubMed
description Cold-inducible RNA-binding protein (CIRP) is an intracellular stress-response protein that can respond to various stress conditions by changing its expression and regulating mRNA stability. As an RNA-binding protein, CIRP modulates gene expression at the post-transcriptional level, including those genes involved in DNA repair, cellular redox metabolism, circadian rhythms, telomere maintenance, and cell survival. CIRP is expressed in a large variety of tissues, including testis, brain, lung, kidney, liver, stomach, bone marrow, and heart. Recent studies have observed the important role of CIRP in cardiac physiology and diseases. CIRP regulates cardiac electrophysiological properties such as the repolarization of cardiomyocytes, the susceptibility of atrial fibrillation, and the function of the sinoatrial node in response to stress. CIRP has also been suggested to protect cardiomyocytes from apoptosis under various stress conditions, including heart failure, high glucose conditions, as well as during extended heart preservation under hypothermic conditions. This review summarizes the findings of CIRP investigations in cardiac physiology and diseases and the underlying molecular mechanism.
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spelling pubmed-79439172021-03-11 The Role of Cold Inducible RNA-Binding Protein in Cardiac Physiology and Diseases Zhong, Peng Peng, Jianye Bian, Zhouyan Huang, He Front Pharmacol Pharmacology Cold-inducible RNA-binding protein (CIRP) is an intracellular stress-response protein that can respond to various stress conditions by changing its expression and regulating mRNA stability. As an RNA-binding protein, CIRP modulates gene expression at the post-transcriptional level, including those genes involved in DNA repair, cellular redox metabolism, circadian rhythms, telomere maintenance, and cell survival. CIRP is expressed in a large variety of tissues, including testis, brain, lung, kidney, liver, stomach, bone marrow, and heart. Recent studies have observed the important role of CIRP in cardiac physiology and diseases. CIRP regulates cardiac electrophysiological properties such as the repolarization of cardiomyocytes, the susceptibility of atrial fibrillation, and the function of the sinoatrial node in response to stress. CIRP has also been suggested to protect cardiomyocytes from apoptosis under various stress conditions, including heart failure, high glucose conditions, as well as during extended heart preservation under hypothermic conditions. This review summarizes the findings of CIRP investigations in cardiac physiology and diseases and the underlying molecular mechanism. Frontiers Media S.A. 2021-02-24 /pmc/articles/PMC7943917/ /pubmed/33716740 http://dx.doi.org/10.3389/fphar.2021.610792 Text en Copyright © 2021 Zhong, Peng, Bian and Huang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhong, Peng
Peng, Jianye
Bian, Zhouyan
Huang, He
The Role of Cold Inducible RNA-Binding Protein in Cardiac Physiology and Diseases
title The Role of Cold Inducible RNA-Binding Protein in Cardiac Physiology and Diseases
title_full The Role of Cold Inducible RNA-Binding Protein in Cardiac Physiology and Diseases
title_fullStr The Role of Cold Inducible RNA-Binding Protein in Cardiac Physiology and Diseases
title_full_unstemmed The Role of Cold Inducible RNA-Binding Protein in Cardiac Physiology and Diseases
title_short The Role of Cold Inducible RNA-Binding Protein in Cardiac Physiology and Diseases
title_sort role of cold inducible rna-binding protein in cardiac physiology and diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943917/
https://www.ncbi.nlm.nih.gov/pubmed/33716740
http://dx.doi.org/10.3389/fphar.2021.610792
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