Cargando…

Efficacy of Platelet-Rich Plasma and Concentrated Growth Factor in Treating Androgenetic Alopecia - A Retrospective Study

INTRODUCTION: Plasma derivatives have been practiced a lot in orthopedics, burns, and sport medicine. Microneedling (MN) with platelet-rich plasma (PRP) therapy has been proven to improve the micro-circulation and thus improve hair growth. The role of concentrated growth factor (CGF) for hair growth...

Descripción completa

Detalles Bibliográficos
Autores principales: Steward, Enosh Nirmalkumar, Patel, Hiren, Pandya, Haren, Dewan, Hitesh, Bhavsar, Bijal, Shah, Urvi, Dholakia, Kartik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943983/
https://www.ncbi.nlm.nih.gov/pubmed/33708587
http://dx.doi.org/10.4103/ams.ams_154_19
_version_ 1783662610148753408
author Steward, Enosh Nirmalkumar
Patel, Hiren
Pandya, Haren
Dewan, Hitesh
Bhavsar, Bijal
Shah, Urvi
Dholakia, Kartik
author_facet Steward, Enosh Nirmalkumar
Patel, Hiren
Pandya, Haren
Dewan, Hitesh
Bhavsar, Bijal
Shah, Urvi
Dholakia, Kartik
author_sort Steward, Enosh Nirmalkumar
collection PubMed
description INTRODUCTION: Plasma derivatives have been practiced a lot in orthopedics, burns, and sport medicine. Microneedling (MN) with platelet-rich plasma (PRP) therapy has been proven to improve the micro-circulation and thus improve hair growth. The role of concentrated growth factor (CGF) for hair growth has not been mentioned anywhere in the literature for hair growth which we tried to prove in our article by comparing it with various other studies. MATERIALS AND METHODS: This is a retrospective randomized study involving 20 male patients whose ages ranged from 21 years to 56 years. PRP was prepared using the dual-spin method and injected after activation; post-MN, CGF gel was applied topically. Four sessions were performed, and a follow-up was done after 6 months. Statistical analysis was done using the Statistical Package for the Social Sciences software version 21 for Windows (SPSS, IBM Corp, Armonk, NY, USA). Paired t-test was used for the various comparisons. RESULTS: Hair loss reduced by the end of the first month. At the end of 6 months, postfirst session, microscopic examination showed statistically significant difference in the hair count compared to those during the baseline. DISCUSSION: PRP having platelet-derived growth factor and vascular endothelial growth factor acts on stem cells in the follicles, stimulating the development of new follicles and promoting neovascularization. CGF helps stimulating cell proliferation and matrix remodeling due to numerous growth factors in a concentrated form. Thus, this therapy combined helps to boost the hair growth in a very significant way. SUMMARY: This study provides the preliminary evidence of efficacy of PRP along with MN and CGF in treating androgenetic alopecia by promoting angiogenesis along with vascularization and promotes hair follicles to enter and extend the anagen phase. Most of the results obtained show improved results with this therapy. A larger case study for the same can further be done for a stronger recommendation of the use of CGF for hair growth therapy further.
format Online
Article
Text
id pubmed-7943983
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-79439832021-03-10 Efficacy of Platelet-Rich Plasma and Concentrated Growth Factor in Treating Androgenetic Alopecia - A Retrospective Study Steward, Enosh Nirmalkumar Patel, Hiren Pandya, Haren Dewan, Hitesh Bhavsar, Bijal Shah, Urvi Dholakia, Kartik Ann Maxillofac Surg Original Article - Retrospective Study INTRODUCTION: Plasma derivatives have been practiced a lot in orthopedics, burns, and sport medicine. Microneedling (MN) with platelet-rich plasma (PRP) therapy has been proven to improve the micro-circulation and thus improve hair growth. The role of concentrated growth factor (CGF) for hair growth has not been mentioned anywhere in the literature for hair growth which we tried to prove in our article by comparing it with various other studies. MATERIALS AND METHODS: This is a retrospective randomized study involving 20 male patients whose ages ranged from 21 years to 56 years. PRP was prepared using the dual-spin method and injected after activation; post-MN, CGF gel was applied topically. Four sessions were performed, and a follow-up was done after 6 months. Statistical analysis was done using the Statistical Package for the Social Sciences software version 21 for Windows (SPSS, IBM Corp, Armonk, NY, USA). Paired t-test was used for the various comparisons. RESULTS: Hair loss reduced by the end of the first month. At the end of 6 months, postfirst session, microscopic examination showed statistically significant difference in the hair count compared to those during the baseline. DISCUSSION: PRP having platelet-derived growth factor and vascular endothelial growth factor acts on stem cells in the follicles, stimulating the development of new follicles and promoting neovascularization. CGF helps stimulating cell proliferation and matrix remodeling due to numerous growth factors in a concentrated form. Thus, this therapy combined helps to boost the hair growth in a very significant way. SUMMARY: This study provides the preliminary evidence of efficacy of PRP along with MN and CGF in treating androgenetic alopecia by promoting angiogenesis along with vascularization and promotes hair follicles to enter and extend the anagen phase. Most of the results obtained show improved results with this therapy. A larger case study for the same can further be done for a stronger recommendation of the use of CGF for hair growth therapy further. Wolters Kluwer - Medknow 2020 2020-12-23 /pmc/articles/PMC7943983/ /pubmed/33708587 http://dx.doi.org/10.4103/ams.ams_154_19 Text en Copyright: © 2020 Annals of Maxillofacial Surgery http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article - Retrospective Study
Steward, Enosh Nirmalkumar
Patel, Hiren
Pandya, Haren
Dewan, Hitesh
Bhavsar, Bijal
Shah, Urvi
Dholakia, Kartik
Efficacy of Platelet-Rich Plasma and Concentrated Growth Factor in Treating Androgenetic Alopecia - A Retrospective Study
title Efficacy of Platelet-Rich Plasma and Concentrated Growth Factor in Treating Androgenetic Alopecia - A Retrospective Study
title_full Efficacy of Platelet-Rich Plasma and Concentrated Growth Factor in Treating Androgenetic Alopecia - A Retrospective Study
title_fullStr Efficacy of Platelet-Rich Plasma and Concentrated Growth Factor in Treating Androgenetic Alopecia - A Retrospective Study
title_full_unstemmed Efficacy of Platelet-Rich Plasma and Concentrated Growth Factor in Treating Androgenetic Alopecia - A Retrospective Study
title_short Efficacy of Platelet-Rich Plasma and Concentrated Growth Factor in Treating Androgenetic Alopecia - A Retrospective Study
title_sort efficacy of platelet-rich plasma and concentrated growth factor in treating androgenetic alopecia - a retrospective study
topic Original Article - Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943983/
https://www.ncbi.nlm.nih.gov/pubmed/33708587
http://dx.doi.org/10.4103/ams.ams_154_19
work_keys_str_mv AT stewardenoshnirmalkumar efficacyofplateletrichplasmaandconcentratedgrowthfactorintreatingandrogeneticalopeciaaretrospectivestudy
AT patelhiren efficacyofplateletrichplasmaandconcentratedgrowthfactorintreatingandrogeneticalopeciaaretrospectivestudy
AT pandyaharen efficacyofplateletrichplasmaandconcentratedgrowthfactorintreatingandrogeneticalopeciaaretrospectivestudy
AT dewanhitesh efficacyofplateletrichplasmaandconcentratedgrowthfactorintreatingandrogeneticalopeciaaretrospectivestudy
AT bhavsarbijal efficacyofplateletrichplasmaandconcentratedgrowthfactorintreatingandrogeneticalopeciaaretrospectivestudy
AT shahurvi efficacyofplateletrichplasmaandconcentratedgrowthfactorintreatingandrogeneticalopeciaaretrospectivestudy
AT dholakiakartik efficacyofplateletrichplasmaandconcentratedgrowthfactorintreatingandrogeneticalopeciaaretrospectivestudy