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Narrative review of stem cell therapy for ischemic brain injury

Ischemic brain injury is a common cause of long-term neurological deficits in children as well as adults, and no efficient treatments could reverse the sequelae in clinic till now. Stem cells have the capacity of self-renewal and multilineage differentiation. The therapeutic efficacy of stem cell tr...

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Autores principales: Ji, Xiao-Li, Ma, Ling, Zhou, Wen-Hao, Xiong, Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944170/
https://www.ncbi.nlm.nih.gov/pubmed/33708530
http://dx.doi.org/10.21037/tp-20-262
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author Ji, Xiao-Li
Ma, Ling
Zhou, Wen-Hao
Xiong, Man
author_facet Ji, Xiao-Li
Ma, Ling
Zhou, Wen-Hao
Xiong, Man
author_sort Ji, Xiao-Li
collection PubMed
description Ischemic brain injury is a common cause of long-term neurological deficits in children as well as adults, and no efficient treatments could reverse the sequelae in clinic till now. Stem cells have the capacity of self-renewal and multilineage differentiation. The therapeutic efficacy of stem cell transplantation for ischemic brain injury have been tested for many years. The grafts could survive and mature in the ischemic brain environment. Stem cell transplantation could improve functional recovery of ischemic brain injury models in pre-clinical trials. The potential mechanisms included cell replacement, release of neurotrophic and anti-inflammatory factors, immunoregulation as well as activation of endogenous neurogenesis. Besides, many clinical trials were conducted and some of trials already had preliminary results. From the current published data, cell transplantation for clinical application is safe and feasible. No severe adverse events and tumorigenesis were reported. While the therapeutic efficacy of stem cell therapy in clinic still needs more evidences. In this review, we overviewed the studies about stem cell therapy for ischemic brain injury. Different types of stem cells used for transplantation as well as the therapeutic mechanisms were discussed in detail. The related pre-clinical and clinical trials were summarized into two separate tables. In addition, we also discussed the unsolved problems and concerns about stem cell therapy for ischemic brain injury that need to be overcome before clinic transformation.
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spelling pubmed-79441702021-03-10 Narrative review of stem cell therapy for ischemic brain injury Ji, Xiao-Li Ma, Ling Zhou, Wen-Hao Xiong, Man Transl Pediatr Review Article Ischemic brain injury is a common cause of long-term neurological deficits in children as well as adults, and no efficient treatments could reverse the sequelae in clinic till now. Stem cells have the capacity of self-renewal and multilineage differentiation. The therapeutic efficacy of stem cell transplantation for ischemic brain injury have been tested for many years. The grafts could survive and mature in the ischemic brain environment. Stem cell transplantation could improve functional recovery of ischemic brain injury models in pre-clinical trials. The potential mechanisms included cell replacement, release of neurotrophic and anti-inflammatory factors, immunoregulation as well as activation of endogenous neurogenesis. Besides, many clinical trials were conducted and some of trials already had preliminary results. From the current published data, cell transplantation for clinical application is safe and feasible. No severe adverse events and tumorigenesis were reported. While the therapeutic efficacy of stem cell therapy in clinic still needs more evidences. In this review, we overviewed the studies about stem cell therapy for ischemic brain injury. Different types of stem cells used for transplantation as well as the therapeutic mechanisms were discussed in detail. The related pre-clinical and clinical trials were summarized into two separate tables. In addition, we also discussed the unsolved problems and concerns about stem cell therapy for ischemic brain injury that need to be overcome before clinic transformation. AME Publishing Company 2021-02 /pmc/articles/PMC7944170/ /pubmed/33708530 http://dx.doi.org/10.21037/tp-20-262 Text en 2021 Translational Pediatrics. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Article
Ji, Xiao-Li
Ma, Ling
Zhou, Wen-Hao
Xiong, Man
Narrative review of stem cell therapy for ischemic brain injury
title Narrative review of stem cell therapy for ischemic brain injury
title_full Narrative review of stem cell therapy for ischemic brain injury
title_fullStr Narrative review of stem cell therapy for ischemic brain injury
title_full_unstemmed Narrative review of stem cell therapy for ischemic brain injury
title_short Narrative review of stem cell therapy for ischemic brain injury
title_sort narrative review of stem cell therapy for ischemic brain injury
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944170/
https://www.ncbi.nlm.nih.gov/pubmed/33708530
http://dx.doi.org/10.21037/tp-20-262
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