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Population attributable risk of excess weight, abdominal obesity and physical inactivity for type 2 diabetes in Chinese men and women

BACKGROUND: Given the high prevalence of type 2 diabetes mellitus (T2DM) in the Chinese population, it is necessary to estimate the T2DM incident attributable to obesity and physical inactivity. METHODS: We analyzed the data from the Shanghai Men’s and Women’s Health Studies, including 56,691 men an...

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Autores principales: Feng, Guo-Shan, Li, Hong-Lan, Shen, Qiu-Ming, Li, Zhuo-Ying, Ji, Xiao-Wei, Xiang, Yong-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944258/
https://www.ncbi.nlm.nih.gov/pubmed/33708953
http://dx.doi.org/10.21037/atm-20-6121
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author Feng, Guo-Shan
Li, Hong-Lan
Shen, Qiu-Ming
Li, Zhuo-Ying
Ji, Xiao-Wei
Xiang, Yong-Bing
author_facet Feng, Guo-Shan
Li, Hong-Lan
Shen, Qiu-Ming
Li, Zhuo-Ying
Ji, Xiao-Wei
Xiang, Yong-Bing
author_sort Feng, Guo-Shan
collection PubMed
description BACKGROUND: Given the high prevalence of type 2 diabetes mellitus (T2DM) in the Chinese population, it is necessary to estimate the T2DM incident attributable to obesity and physical inactivity. METHODS: We analyzed the data from the Shanghai Men’s and Women’s Health Studies, including 56,691 men and 70,849 women aged 40–74. The hazard ratios (HRs) and the population attributable risks (PARs) were calculated by Cox regression model and model-based estimation. RESULTS: A total of 3,315 male and 5,925 female cases were identified during 519,157 and 981,504 person-years, up to 31 December 2017. Excess weight, abdominal obesity were associated with the increased risks of T2DM both in women and men, while physical inactivity was only associated with an increased risk in men. A large proportion of T2DM incident cases can be attributed to excess body weight (women: 48.6%; men: 41.5%) and abdominal obesity (women: 50.4%; men: 30.3%). Physical activity was negatively associated with the risk of T2DM (P(trend)<0.01). The PARs adjusted for confounders were 3.6% for physical inactivity in men and 1.7% in women. CONCLUSIONS: Excess weight and abdominal obesity accounted for a large proportion of T2DM incident cases in men and women; a small part of T2DM cases were attributed to physical inactivity in men. Weight control is of great significance in curbing the epidemic of diabetes.
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spelling pubmed-79442582021-03-10 Population attributable risk of excess weight, abdominal obesity and physical inactivity for type 2 diabetes in Chinese men and women Feng, Guo-Shan Li, Hong-Lan Shen, Qiu-Ming Li, Zhuo-Ying Ji, Xiao-Wei Xiang, Yong-Bing Ann Transl Med Original Article BACKGROUND: Given the high prevalence of type 2 diabetes mellitus (T2DM) in the Chinese population, it is necessary to estimate the T2DM incident attributable to obesity and physical inactivity. METHODS: We analyzed the data from the Shanghai Men’s and Women’s Health Studies, including 56,691 men and 70,849 women aged 40–74. The hazard ratios (HRs) and the population attributable risks (PARs) were calculated by Cox regression model and model-based estimation. RESULTS: A total of 3,315 male and 5,925 female cases were identified during 519,157 and 981,504 person-years, up to 31 December 2017. Excess weight, abdominal obesity were associated with the increased risks of T2DM both in women and men, while physical inactivity was only associated with an increased risk in men. A large proportion of T2DM incident cases can be attributed to excess body weight (women: 48.6%; men: 41.5%) and abdominal obesity (women: 50.4%; men: 30.3%). Physical activity was negatively associated with the risk of T2DM (P(trend)<0.01). The PARs adjusted for confounders were 3.6% for physical inactivity in men and 1.7% in women. CONCLUSIONS: Excess weight and abdominal obesity accounted for a large proportion of T2DM incident cases in men and women; a small part of T2DM cases were attributed to physical inactivity in men. Weight control is of great significance in curbing the epidemic of diabetes. AME Publishing Company 2021-02 /pmc/articles/PMC7944258/ /pubmed/33708953 http://dx.doi.org/10.21037/atm-20-6121 Text en 2021 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Feng, Guo-Shan
Li, Hong-Lan
Shen, Qiu-Ming
Li, Zhuo-Ying
Ji, Xiao-Wei
Xiang, Yong-Bing
Population attributable risk of excess weight, abdominal obesity and physical inactivity for type 2 diabetes in Chinese men and women
title Population attributable risk of excess weight, abdominal obesity and physical inactivity for type 2 diabetes in Chinese men and women
title_full Population attributable risk of excess weight, abdominal obesity and physical inactivity for type 2 diabetes in Chinese men and women
title_fullStr Population attributable risk of excess weight, abdominal obesity and physical inactivity for type 2 diabetes in Chinese men and women
title_full_unstemmed Population attributable risk of excess weight, abdominal obesity and physical inactivity for type 2 diabetes in Chinese men and women
title_short Population attributable risk of excess weight, abdominal obesity and physical inactivity for type 2 diabetes in Chinese men and women
title_sort population attributable risk of excess weight, abdominal obesity and physical inactivity for type 2 diabetes in chinese men and women
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944258/
https://www.ncbi.nlm.nih.gov/pubmed/33708953
http://dx.doi.org/10.21037/atm-20-6121
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