Accuracy of intraocular lens calculation formulas for eyes with insufficient capsular support

BACKGROUND: There is no consensus on which intraocular lens (IOL) power calculation formula provides the best refractive prediction in patients with inadequate capsular support whose anterior ocular anatomic structure differs from that of normal subjects. Therefore, the purpose of this study was to analyze the accuracy and performance of IOL calculation formulas (SRK/T, Holladay 1, Hoffer Q, Haigis, and Barrett Universal II) in predicting postoperative refractive prediction error (PE) for this subgroup of patients. METHODS: A total of 110 eyes from 110 patients with insufficient capsular support who underwent scleral fixation of an IOL at the Zhongshan Ophthalmic Center from July 1, 2016 to November 30, 2019 were enrolled in this retrospective study. Preoperative optical biometrics were measured with the IOL Master 500 (Carl Zeiss, Oberkochen, Germany). The performance of each formula in predicting PE was compared, and the effect of keratometry and axial length (AL) on PE was evaluated for each formula using univariate and multivariate linear regression analysis. RESULTS: The mean age of the included participants was 12.54±9.66 years. The Sanders, Retzlaff, and Manus/theoretical (SRK/T) (−0.25 D) and Holladay 1 (−0.28 D) formulas tended to have minimal postoperative PE compared to the Hoffer Q (−0.62 D), Haigis (−0.67 D), and Barrett Universal II (−0.62 D) formulas (P=0.005). All formulas individually resulted in <70% of eyes within ±1.00 D of the PE. Nevertheless, after constants were optimized, these formulas led to 7.3% to 13.6% of increase within ±1.00 D of the PE. Keratometry and AL were significantly associated with PE for each formula, but the relationship was weakest for SRK/T. CONCLUSIONS: In eyes with insufficient capsular support, postoperative PE was minimal for the SRK/T formula, which suggested SRK/T to be the best choice, especially when the keratometry and AL of patients are extremely large or small.