ALS2 regulates endosomal trafficking, postsynaptic development, and neuronal survival

Mutations in the human ALS2 gene cause recessive juvenile-onset amyotrophic lateral sclerosis and related motor neuron diseases. Although the ALS2 protein has been identified as a guanine-nucleotide exchange factor for the small GTPase Rab5, its physiological roles remain largely unknown. Here, we d...

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Detalles Bibliográficos
Autores principales: Kim, Joohyung, Kim, Sungdae, Nahm, Minyeop, Li, Tsai-Ning, Lin, Hsin-Chieh, Kim, Yeongjin David, Lee, Jihye, Yao, Chi-Kuang, Lee, Seungbok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944400/
https://www.ncbi.nlm.nih.gov/pubmed/33683284
http://dx.doi.org/10.1083/jcb.202007112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944400/
https://www.ncbi.nlm.nih.gov/pubmed/33683284
http://dx.doi.org/10.1083/jcb.202007112

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