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Priming with DNA Expressing Trimeric HIV V1V2 Alters the Immune Hierarchy Favoring the Development of V2-Specific Antibodies in Rhesus Macaques

The RV144 vaccine trial revealed a correlation between reduced risk of HIV infection and the level of nonneutralizing-antibody (Ab) responses targeting specific epitopes in the second variable domain (V2) of the HIV gp120 envelope (Env) protein, suggesting this region as a target for vaccine develop...

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Autores principales:	Devasundaram, Santhi, Rosati, Margherita, Valentin, Antonio, Weiss, Svenja, Itri, Vincenza, Trinh, Hung V., Bear, Jenifer, Chowdhury, Bhabadeb, LaBranche, Celia C., Montefiori, David, Ferrari, Guido, Rao, Mangala, Kong, Xiang-Peng, Zolla-Pazner, Susan, Pavlakis, George N., Felber, Barbara K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Vaccines and Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944456/ https://www.ncbi.nlm.nih.gov/pubmed/33087466 http://dx.doi.org/10.1128/JVI.01193-20

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