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Ustekinumab-induced chronic lymphocytic leukemia in a patient with psoriatic arthritis
Psoriatic arthritis (PsA) is a chronic inflammatory disease characterized by skin and joint involvement. The disease may present with various joint pattern involvement, which sometimes may lead to joint destruction and deformity. Early diagnosis and treatment with disease-modifying anti-rheumatic dr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944959/ https://www.ncbi.nlm.nih.gov/pubmed/33707797 http://dx.doi.org/10.5114/reum.2021.102618 |
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author | Gediz, Fusun Ugur, Mehmet Can Turkmen, Meltem Kobak, Senol |
author_facet | Gediz, Fusun Ugur, Mehmet Can Turkmen, Meltem Kobak, Senol |
author_sort | Gediz, Fusun |
collection | PubMed |
description | Psoriatic arthritis (PsA) is a chronic inflammatory disease characterized by skin and joint involvement. The disease may present with various joint pattern involvement, which sometimes may lead to joint destruction and deformity. Early diagnosis and treatment with disease-modifying anti-rheumatic drugs may prevent joint deformity. Recently there are many new treatment options including biologic drugs. Ustekinumab, an interleukin 12/23 inhibitor, has proven efficacy in the treatment of psoriatic arthritis. Like other biologic drugs (anti-TNF-α), there are contradictory data about the safety of ustekinumab and possible relationship with cancer development. Herein we report the development of chronic lymphocytic leukemia in a patient with PsA treated with ustekinumab. |
format | Online Article Text |
id | pubmed-7944959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie |
record_format | MEDLINE/PubMed |
spelling | pubmed-79449592021-03-10 Ustekinumab-induced chronic lymphocytic leukemia in a patient with psoriatic arthritis Gediz, Fusun Ugur, Mehmet Can Turkmen, Meltem Kobak, Senol Reumatologia Case-Based Review Psoriatic arthritis (PsA) is a chronic inflammatory disease characterized by skin and joint involvement. The disease may present with various joint pattern involvement, which sometimes may lead to joint destruction and deformity. Early diagnosis and treatment with disease-modifying anti-rheumatic drugs may prevent joint deformity. Recently there are many new treatment options including biologic drugs. Ustekinumab, an interleukin 12/23 inhibitor, has proven efficacy in the treatment of psoriatic arthritis. Like other biologic drugs (anti-TNF-α), there are contradictory data about the safety of ustekinumab and possible relationship with cancer development. Herein we report the development of chronic lymphocytic leukemia in a patient with PsA treated with ustekinumab. Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2021-02-28 2021 /pmc/articles/PMC7944959/ /pubmed/33707797 http://dx.doi.org/10.5114/reum.2021.102618 Text en Copyright: © 2021 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Case-Based Review Gediz, Fusun Ugur, Mehmet Can Turkmen, Meltem Kobak, Senol Ustekinumab-induced chronic lymphocytic leukemia in a patient with psoriatic arthritis |
title | Ustekinumab-induced chronic lymphocytic leukemia in a patient with psoriatic arthritis |
title_full | Ustekinumab-induced chronic lymphocytic leukemia in a patient with psoriatic arthritis |
title_fullStr | Ustekinumab-induced chronic lymphocytic leukemia in a patient with psoriatic arthritis |
title_full_unstemmed | Ustekinumab-induced chronic lymphocytic leukemia in a patient with psoriatic arthritis |
title_short | Ustekinumab-induced chronic lymphocytic leukemia in a patient with psoriatic arthritis |
title_sort | ustekinumab-induced chronic lymphocytic leukemia in a patient with psoriatic arthritis |
topic | Case-Based Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944959/ https://www.ncbi.nlm.nih.gov/pubmed/33707797 http://dx.doi.org/10.5114/reum.2021.102618 |
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