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HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice

Regulatory T (T(reg)) cells are essential to maintain immune homeostasis in the intestine and T(reg) cell dysfunction is associated with several inflammatory and autoimmune disorders including inflammatory bowel disease (IBD). Efforts using low-dose (LD) interleukin-2 (IL-2) to expand autologous T(r...

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Detalles Bibliográficos
Autores principales:	Tyagi, Rajeev K., Jacobse, Justin, Li, Jing, Allaman, Margret M., Otipoby, Kevin L., Sampson, Erik R., Wilson, Keith T., Goettel, Jeremy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945590/ https://www.ncbi.nlm.nih.gov/pubmed/33717161 http://dx.doi.org/10.3389/fimmu.2021.630204

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