Non-Coding RNAs Participate in the Pathogenesis of Neuroblastoma

Neuroblastoma is one of the utmost frequent neoplasms during the first year of life. This pediatric cancer is believed to be originated during the embryonic life from the neural crest cells. Previous studies have detected several types of chromosomal aberrations in this tumor. More recent studies ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Rezaei, Omidvar, Honarmand Tamizkar, Kasra, Hajiesmaeili, Mohammadreza, Taheri, Mohammad, Ghafouri-Fard, Soudeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945591/
https://www.ncbi.nlm.nih.gov/pubmed/33718173
http://dx.doi.org/10.3389/fonc.2021.617362
_version_ 1783662887632371712
author Rezaei, Omidvar
Honarmand Tamizkar, Kasra
Hajiesmaeili, Mohammadreza
Taheri, Mohammad
Ghafouri-Fard, Soudeh
author_facet Rezaei, Omidvar
Honarmand Tamizkar, Kasra
Hajiesmaeili, Mohammadreza
Taheri, Mohammad
Ghafouri-Fard, Soudeh
author_sort Rezaei, Omidvar
collection PubMed
description Neuroblastoma is one of the utmost frequent neoplasms during the first year of life. This pediatric cancer is believed to be originated during the embryonic life from the neural crest cells. Previous studies have detected several types of chromosomal aberrations in this tumor. More recent studies have emphasized on expression profiling of neuroblastoma samples to identify the dysregulated genes in this type of cancer. Non-coding RNAs are among the mostly dysregulated genes in this type of cancer. Such dysregulation has been associated with a number of chromosomal aberrations that are frequently detected in neuroblastoma. In this study, we explain the role of non-coding transcripts in the malignant transformation in neuroblastoma and their role as biomarkers for this pediatric cancer.
format Online
Article
Text
id pubmed-7945591
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-79455912021-03-11 Non-Coding RNAs Participate in the Pathogenesis of Neuroblastoma Rezaei, Omidvar Honarmand Tamizkar, Kasra Hajiesmaeili, Mohammadreza Taheri, Mohammad Ghafouri-Fard, Soudeh Front Oncol Oncology Neuroblastoma is one of the utmost frequent neoplasms during the first year of life. This pediatric cancer is believed to be originated during the embryonic life from the neural crest cells. Previous studies have detected several types of chromosomal aberrations in this tumor. More recent studies have emphasized on expression profiling of neuroblastoma samples to identify the dysregulated genes in this type of cancer. Non-coding RNAs are among the mostly dysregulated genes in this type of cancer. Such dysregulation has been associated with a number of chromosomal aberrations that are frequently detected in neuroblastoma. In this study, we explain the role of non-coding transcripts in the malignant transformation in neuroblastoma and their role as biomarkers for this pediatric cancer. Frontiers Media S.A. 2021-02-24 /pmc/articles/PMC7945591/ /pubmed/33718173 http://dx.doi.org/10.3389/fonc.2021.617362 Text en Copyright © 2021 Rezaei, Honarmand Tamizkar, Hajiesmaeili, Taheri and Ghafouri-Fard http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Rezaei, Omidvar
Honarmand Tamizkar, Kasra
Hajiesmaeili, Mohammadreza
Taheri, Mohammad
Ghafouri-Fard, Soudeh
Non-Coding RNAs Participate in the Pathogenesis of Neuroblastoma
title Non-Coding RNAs Participate in the Pathogenesis of Neuroblastoma
title_full Non-Coding RNAs Participate in the Pathogenesis of Neuroblastoma
title_fullStr Non-Coding RNAs Participate in the Pathogenesis of Neuroblastoma
title_full_unstemmed Non-Coding RNAs Participate in the Pathogenesis of Neuroblastoma
title_short Non-Coding RNAs Participate in the Pathogenesis of Neuroblastoma
title_sort non-coding rnas participate in the pathogenesis of neuroblastoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945591/
https://www.ncbi.nlm.nih.gov/pubmed/33718173
http://dx.doi.org/10.3389/fonc.2021.617362
work_keys_str_mv AT rezaeiomidvar noncodingrnasparticipateinthepathogenesisofneuroblastoma
AT honarmandtamizkarkasra noncodingrnasparticipateinthepathogenesisofneuroblastoma
AT hajiesmaeilimohammadreza noncodingrnasparticipateinthepathogenesisofneuroblastoma
AT taherimohammad noncodingrnasparticipateinthepathogenesisofneuroblastoma
AT ghafourifardsoudeh noncodingrnasparticipateinthepathogenesisofneuroblastoma

Ejemplares similares