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Optic Nerve Head Changes in Patients with Optic Neuritis Secondary to Multiple Sclerosis: A Comparison of the Affected and Fellow Healthy Eyes

OBJECTIVE: To evaluate the thickness of lamina cribrosa (LC) in patients with multiple sclerosis (MS) using optical coherence tomography (OCT) and the effect of optic neuritis (ON) attack on these measurements during the remission period. METHODS: The study included 20 cases diagnosed with relapsing...

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Autores principales: Balci, Sevcan, Yildiz, Merve Beyza, Ozcelik Kose, Alev, Suer, Devran, Turan Vural, Ece, Emir, Canan, Yenerel, Nursal Melda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Istanbul Medeniyet University 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945731/
https://www.ncbi.nlm.nih.gov/pubmed/33717626
http://dx.doi.org/10.5222/MMJ.2020.99075
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author Balci, Sevcan
Yildiz, Merve Beyza
Ozcelik Kose, Alev
Suer, Devran
Turan Vural, Ece
Emir, Canan
Yenerel, Nursal Melda
author_facet Balci, Sevcan
Yildiz, Merve Beyza
Ozcelik Kose, Alev
Suer, Devran
Turan Vural, Ece
Emir, Canan
Yenerel, Nursal Melda
author_sort Balci, Sevcan
collection PubMed
description OBJECTIVE: To evaluate the thickness of lamina cribrosa (LC) in patients with multiple sclerosis (MS) using optical coherence tomography (OCT) and the effect of optic neuritis (ON) attack on these measurements during the remission period. METHODS: The study included 20 cases diagnosed with relapsing-remitting MS with a history of ON attacks affecting one eye and in remission of MS and ON attacks for at least three months, and 28 randomly selected eyes of age- and sex-matched healthy controls. In the MS group, the eyes affected by ON attack were assigned as Group 1 (MS+ON), their fellow unaffected eyes as Group 2 (MS-ON), and healthy control eyes as Group 3. The LC, peripapillary retinal nerve fiber layer (ppRNFL), and subfoveal choroidal thickness measurements were made by using OCT in all cases, and results were compared between the groups. RESULTS: The mean LC thickness in MS+ON and MS-ON groups was significantly lower than the control group (p<0.001). There was no significant difference between MS+ON and MS-ON groups in terms of mean LC thickness (p=0.073). The mean ppRNFL in the MS+ON and MS-ON groups was statistically significantly lower than the control group (p=0.003, p=0.035, respectively). CONCLUSIONS: It is noteworthy that LC is significantly affected in eyes with MS who have not had a history of ON attack. Evaluation of the LC measurements can be important for early detection of optic nerve damage in patients with MS.
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spelling pubmed-79457312021-03-11 Optic Nerve Head Changes in Patients with Optic Neuritis Secondary to Multiple Sclerosis: A Comparison of the Affected and Fellow Healthy Eyes Balci, Sevcan Yildiz, Merve Beyza Ozcelik Kose, Alev Suer, Devran Turan Vural, Ece Emir, Canan Yenerel, Nursal Melda Medeni Med J Original Study OBJECTIVE: To evaluate the thickness of lamina cribrosa (LC) in patients with multiple sclerosis (MS) using optical coherence tomography (OCT) and the effect of optic neuritis (ON) attack on these measurements during the remission period. METHODS: The study included 20 cases diagnosed with relapsing-remitting MS with a history of ON attacks affecting one eye and in remission of MS and ON attacks for at least three months, and 28 randomly selected eyes of age- and sex-matched healthy controls. In the MS group, the eyes affected by ON attack were assigned as Group 1 (MS+ON), their fellow unaffected eyes as Group 2 (MS-ON), and healthy control eyes as Group 3. The LC, peripapillary retinal nerve fiber layer (ppRNFL), and subfoveal choroidal thickness measurements were made by using OCT in all cases, and results were compared between the groups. RESULTS: The mean LC thickness in MS+ON and MS-ON groups was significantly lower than the control group (p<0.001). There was no significant difference between MS+ON and MS-ON groups in terms of mean LC thickness (p=0.073). The mean ppRNFL in the MS+ON and MS-ON groups was statistically significantly lower than the control group (p=0.003, p=0.035, respectively). CONCLUSIONS: It is noteworthy that LC is significantly affected in eyes with MS who have not had a history of ON attack. Evaluation of the LC measurements can be important for early detection of optic nerve damage in patients with MS. Istanbul Medeniyet University 2020 2020-12-25 /pmc/articles/PMC7945731/ /pubmed/33717626 http://dx.doi.org/10.5222/MMJ.2020.99075 Text en © Copyright Istanbul Medeniyet University Faculty of Medicine. http://creativecommons.org/licenses/by-nc/4.0/ This journal is published by Logos Medical Publishing. Licenced by Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
spellingShingle Original Study
Balci, Sevcan
Yildiz, Merve Beyza
Ozcelik Kose, Alev
Suer, Devran
Turan Vural, Ece
Emir, Canan
Yenerel, Nursal Melda
Optic Nerve Head Changes in Patients with Optic Neuritis Secondary to Multiple Sclerosis: A Comparison of the Affected and Fellow Healthy Eyes
title Optic Nerve Head Changes in Patients with Optic Neuritis Secondary to Multiple Sclerosis: A Comparison of the Affected and Fellow Healthy Eyes
title_full Optic Nerve Head Changes in Patients with Optic Neuritis Secondary to Multiple Sclerosis: A Comparison of the Affected and Fellow Healthy Eyes
title_fullStr Optic Nerve Head Changes in Patients with Optic Neuritis Secondary to Multiple Sclerosis: A Comparison of the Affected and Fellow Healthy Eyes
title_full_unstemmed Optic Nerve Head Changes in Patients with Optic Neuritis Secondary to Multiple Sclerosis: A Comparison of the Affected and Fellow Healthy Eyes
title_short Optic Nerve Head Changes in Patients with Optic Neuritis Secondary to Multiple Sclerosis: A Comparison of the Affected and Fellow Healthy Eyes
title_sort optic nerve head changes in patients with optic neuritis secondary to multiple sclerosis: a comparison of the affected and fellow healthy eyes
topic Original Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945731/
https://www.ncbi.nlm.nih.gov/pubmed/33717626
http://dx.doi.org/10.5222/MMJ.2020.99075
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