Fc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activation

Fc galactosylation is a critical quality attribute for anti-tumor recombinant immunoglobulin G (IgG)-based monoclonal antibody (mAb) therapeutics with complement-dependent cytotoxicity (CDC) as the mechanism of action. Although the correlation between galactosylation and CDC has been known, the unde...

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Detalles Bibliográficos
Autores principales: Wei, Bingchuan, Gao, Xuan, Cadang, Lance, Izadi, Saeed, Liu, Peilu, Zhang, Hui-Min, Hecht, Elizabeth, Shim, Jeongsup, Magill, Gordon, Pabon, Juan Rincon, Dai, Lu, Phung, Wilson, Lin, Elaine, Wang, Christopher, Whang, Kevin, Sanchez, Sean, Oropeza Jr, Jose, Camperi, Julien, Zhang, Jennifer, Sandoval, Wendy, Zhang, Yonghua Taylor, Jiang, Guoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946005/
https://www.ncbi.nlm.nih.gov/pubmed/33682619
http://dx.doi.org/10.1080/19420862.2021.1893427

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