Evaluation of transgene expression characteristics and DNA vaccination against melanoma metastasis of an intravenously injected ternary complex with biodegradable dendrigraft poly-L-lysine in mice

We developed a biocompatible splenic vector for a DNA vaccine against melanoma. The splenic vector is a ternary complex composed of plasmid DNA (pDNA), biodegradable dendrigraft poly-L-lysine (DGL), and γ-polyglutamic acid (γ-PGA), the selective uptake of which by the spleen has already been demonst...

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Detalles Bibliográficos
Autores principales: Kodama, Yukinobu, Tokunaga, Ayako, Hashizume, Junya, Nakagawa, Hiroo, Harasawa, Hitomi, Kurosaki, Tomoaki, Nakamura, Tadahiro, Nishida, Koyo, Nakashima, Mikiro, Hashida, Mitsuru, Kawakami, Shigeru, Sasaki, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946064/
https://www.ncbi.nlm.nih.gov/pubmed/33685317
http://dx.doi.org/10.1080/10717544.2021.1895904

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