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Recent advances in understanding tight junctions
Tight junctions (TJs) are one type of cell–cell junction in epithelial cell types in vertebrates. They form a paracellular diffusion barrier and create the boundary between the apical and basolateral plasma membrane domains. The molecular constituents of TJs have mostly been identified, and now thei...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculty Opinions Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946388/ https://www.ncbi.nlm.nih.gov/pubmed/33718935 http://dx.doi.org/10.12703/r/10-18 |
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author | Furuse, Mikio Takai, Yoshimi |
author_facet | Furuse, Mikio Takai, Yoshimi |
author_sort | Furuse, Mikio |
collection | PubMed |
description | Tight junctions (TJs) are one type of cell–cell junction in epithelial cell types in vertebrates. They form a paracellular diffusion barrier and create the boundary between the apical and basolateral plasma membrane domains. The molecular constituents of TJs have mostly been identified, and now their cell biology has shifted to understanding of their formation, dynamics, and functional regulation as well as their relationship to the organization of epithelial cells. Accumulating novel findings are supported by new methods, including super-resolution microscopy, quantitative microscopy, biophysical measurements, and genome editing-mediated gene manipulation. As a conceptual breakthrough, liquid-liquid phase separation seems to be involved in the formation of TJs as super-molecular complexes. This short article summarizes seminal studies in the cell biology of TJs from the last three years. |
format | Online Article Text |
id | pubmed-7946388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Faculty Opinions Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-79463882021-03-12 Recent advances in understanding tight junctions Furuse, Mikio Takai, Yoshimi Fac Rev Review Article Tight junctions (TJs) are one type of cell–cell junction in epithelial cell types in vertebrates. They form a paracellular diffusion barrier and create the boundary between the apical and basolateral plasma membrane domains. The molecular constituents of TJs have mostly been identified, and now their cell biology has shifted to understanding of their formation, dynamics, and functional regulation as well as their relationship to the organization of epithelial cells. Accumulating novel findings are supported by new methods, including super-resolution microscopy, quantitative microscopy, biophysical measurements, and genome editing-mediated gene manipulation. As a conceptual breakthrough, liquid-liquid phase separation seems to be involved in the formation of TJs as super-molecular complexes. This short article summarizes seminal studies in the cell biology of TJs from the last three years. Faculty Opinions Ltd 2021-02-23 /pmc/articles/PMC7946388/ /pubmed/33718935 http://dx.doi.org/10.12703/r/10-18 Text en Copyright: © 2021 Furuse M et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Furuse, Mikio Takai, Yoshimi Recent advances in understanding tight junctions |
title | Recent advances in understanding tight junctions |
title_full | Recent advances in understanding tight junctions |
title_fullStr | Recent advances in understanding tight junctions |
title_full_unstemmed | Recent advances in understanding tight junctions |
title_short | Recent advances in understanding tight junctions |
title_sort | recent advances in understanding tight junctions |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946388/ https://www.ncbi.nlm.nih.gov/pubmed/33718935 http://dx.doi.org/10.12703/r/10-18 |
work_keys_str_mv | AT furusemikio recentadvancesinunderstandingtightjunctions AT takaiyoshimi recentadvancesinunderstandingtightjunctions |