Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism

Interleukin-4-induced-1 (IL4i1) is an amino acid oxidase secreted from immune cells. Recent observations have suggested that IL4i1 is pro-tumorigenic via unknown mechanisms. As IL4i1 has homologs in snake venoms (L-amino acid oxidases [LAAO]), we used comparative approaches to gain insight into the...

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Detalles Bibliográficos
Autores principales: Zeitler, Leonie, Fiore, Alessandra, Meyer, Claudia, Russier, Marion, Zanella, Gaia, Suppmann, Sabine, Gargaro, Marco, Sidhu, Sachdev S, Seshagiri, Somasekar, Ohnmacht, Caspar, Köcher, Thomas, Fallarino, Francesca, Linkermann, Andreas, Murray, Peter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946422/
https://www.ncbi.nlm.nih.gov/pubmed/33646117
http://dx.doi.org/10.7554/eLife.64806

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