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Obstructive Jaundice Due to Duodenal Ulcer Induced by Lenvatinib Therapy for Hepatocellular Carcinoma
An 82-year-old man with hepatocellular carcinoma presented with upper abdominal pain, vomiting, and jaundice. He had been taking a standard lenvatinib dose for three months. Although acute cholangitis was suggested, imaging studies failed to detect the biliary obstruction site. An endoscopic examina...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946507/ https://www.ncbi.nlm.nih.gov/pubmed/33028766 http://dx.doi.org/10.2169/internalmedicine.5097-20 |
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author | Suoh, Maito Hagihara, Atsushi Yamamura, Masafumi Maruyama, Hirotsugu Taira, Koichi Enomoto, Masaru Tamori, Akihiro Fujiwara, Yasuhiro Kawada, Norifumi |
author_facet | Suoh, Maito Hagihara, Atsushi Yamamura, Masafumi Maruyama, Hirotsugu Taira, Koichi Enomoto, Masaru Tamori, Akihiro Fujiwara, Yasuhiro Kawada, Norifumi |
author_sort | Suoh, Maito |
collection | PubMed |
description | An 82-year-old man with hepatocellular carcinoma presented with upper abdominal pain, vomiting, and jaundice. He had been taking a standard lenvatinib dose for three months. Although acute cholangitis was suggested, imaging studies failed to detect the biliary obstruction site. An endoscopic examination following discontinuation of lenvatinib and aspirin revealed multiple duodenal ulcers, one of which was formed on the ampulla of Vater and causing cholestasis. Endoscopic biliary drainage and antibiotics improved concomitant Enterobacter cloacae bacteremia. Ulcer healing was confirmed after rabeprazole was replaced with vonoprazan and misoprostol. Our case shows that lenvatinib can induce duodenal ulcers resulting in obstructive jaundice. |
format | Online Article Text |
id | pubmed-7946507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-79465072021-03-15 Obstructive Jaundice Due to Duodenal Ulcer Induced by Lenvatinib Therapy for Hepatocellular Carcinoma Suoh, Maito Hagihara, Atsushi Yamamura, Masafumi Maruyama, Hirotsugu Taira, Koichi Enomoto, Masaru Tamori, Akihiro Fujiwara, Yasuhiro Kawada, Norifumi Intern Med Case Report An 82-year-old man with hepatocellular carcinoma presented with upper abdominal pain, vomiting, and jaundice. He had been taking a standard lenvatinib dose for three months. Although acute cholangitis was suggested, imaging studies failed to detect the biliary obstruction site. An endoscopic examination following discontinuation of lenvatinib and aspirin revealed multiple duodenal ulcers, one of which was formed on the ampulla of Vater and causing cholestasis. Endoscopic biliary drainage and antibiotics improved concomitant Enterobacter cloacae bacteremia. Ulcer healing was confirmed after rabeprazole was replaced with vonoprazan and misoprostol. Our case shows that lenvatinib can induce duodenal ulcers resulting in obstructive jaundice. The Japanese Society of Internal Medicine 2020-10-07 2021-02-15 /pmc/articles/PMC7946507/ /pubmed/33028766 http://dx.doi.org/10.2169/internalmedicine.5097-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Suoh, Maito Hagihara, Atsushi Yamamura, Masafumi Maruyama, Hirotsugu Taira, Koichi Enomoto, Masaru Tamori, Akihiro Fujiwara, Yasuhiro Kawada, Norifumi Obstructive Jaundice Due to Duodenal Ulcer Induced by Lenvatinib Therapy for Hepatocellular Carcinoma |
title | Obstructive Jaundice Due to Duodenal Ulcer Induced by Lenvatinib Therapy for Hepatocellular Carcinoma |
title_full | Obstructive Jaundice Due to Duodenal Ulcer Induced by Lenvatinib Therapy for Hepatocellular Carcinoma |
title_fullStr | Obstructive Jaundice Due to Duodenal Ulcer Induced by Lenvatinib Therapy for Hepatocellular Carcinoma |
title_full_unstemmed | Obstructive Jaundice Due to Duodenal Ulcer Induced by Lenvatinib Therapy for Hepatocellular Carcinoma |
title_short | Obstructive Jaundice Due to Duodenal Ulcer Induced by Lenvatinib Therapy for Hepatocellular Carcinoma |
title_sort | obstructive jaundice due to duodenal ulcer induced by lenvatinib therapy for hepatocellular carcinoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946507/ https://www.ncbi.nlm.nih.gov/pubmed/33028766 http://dx.doi.org/10.2169/internalmedicine.5097-20 |
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