Asymptomatic Immune Checkpoint Inhibitor-associated Myocarditis

We herein report the case of a 75-year-old man with asymptomatic immune checkpoint inhibitor (ICI)-associated myocarditis diagnosed on the basis of elevated levels of creatine kinase (CK), CK-myocardial band and troponin I (TNI). He was suspected of being complicated with myasthenia gravis (MG). Hig...

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Detalles Bibliográficos
Autores principales: Tanabe, Junya, Watanabe, Nobuhide, Endo, Akihiro, Nagami, Taichi, Inagaki, Satoshi, Tanabe, Kazuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946516/
https://www.ncbi.nlm.nih.gov/pubmed/33028770
http://dx.doi.org/10.2169/internalmedicine.5412-20
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author Tanabe, Junya
Watanabe, Nobuhide
Endo, Akihiro
Nagami, Taichi
Inagaki, Satoshi
Tanabe, Kazuaki
author_facet Tanabe, Junya
Watanabe, Nobuhide
Endo, Akihiro
Nagami, Taichi
Inagaki, Satoshi
Tanabe, Kazuaki
author_sort Tanabe, Junya
collection PubMed
description We herein report the case of a 75-year-old man with asymptomatic immune checkpoint inhibitor (ICI)-associated myocarditis diagnosed on the basis of elevated levels of creatine kinase (CK), CK-myocardial band and troponin I (TNI). He was suspected of being complicated with myasthenia gravis (MG). High-dose prednisolone (PSL) is associated with a risk of MG exacerbation; therefore, PSL therapy was gradually increased from 5 mg/day to 20 mg/day, which resulted in the normalization of the TNI level, and no PSL-related side effects occurred. MG easily complicates myocarditis as an immune-related adverse event; thus, the treatment plan should be carefully considered.
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spelling pubmed-79465162021-03-15 Asymptomatic Immune Checkpoint Inhibitor-associated Myocarditis Tanabe, Junya Watanabe, Nobuhide Endo, Akihiro Nagami, Taichi Inagaki, Satoshi Tanabe, Kazuaki Intern Med Case Report We herein report the case of a 75-year-old man with asymptomatic immune checkpoint inhibitor (ICI)-associated myocarditis diagnosed on the basis of elevated levels of creatine kinase (CK), CK-myocardial band and troponin I (TNI). He was suspected of being complicated with myasthenia gravis (MG). High-dose prednisolone (PSL) is associated with a risk of MG exacerbation; therefore, PSL therapy was gradually increased from 5 mg/day to 20 mg/day, which resulted in the normalization of the TNI level, and no PSL-related side effects occurred. MG easily complicates myocarditis as an immune-related adverse event; thus, the treatment plan should be carefully considered. The Japanese Society of Internal Medicine 2020-10-07 2021-02-15 /pmc/articles/PMC7946516/ /pubmed/33028770 http://dx.doi.org/10.2169/internalmedicine.5412-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tanabe, Junya
Watanabe, Nobuhide
Endo, Akihiro
Nagami, Taichi
Inagaki, Satoshi
Tanabe, Kazuaki
Asymptomatic Immune Checkpoint Inhibitor-associated Myocarditis
title Asymptomatic Immune Checkpoint Inhibitor-associated Myocarditis
title_full Asymptomatic Immune Checkpoint Inhibitor-associated Myocarditis
title_fullStr Asymptomatic Immune Checkpoint Inhibitor-associated Myocarditis
title_full_unstemmed Asymptomatic Immune Checkpoint Inhibitor-associated Myocarditis
title_short Asymptomatic Immune Checkpoint Inhibitor-associated Myocarditis
title_sort asymptomatic immune checkpoint inhibitor-associated myocarditis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946516/
https://www.ncbi.nlm.nih.gov/pubmed/33028770
http://dx.doi.org/10.2169/internalmedicine.5412-20
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AT nagamitaichi asymptomaticimmunecheckpointinhibitorassociatedmyocarditis
AT inagakisatoshi asymptomaticimmunecheckpointinhibitorassociatedmyocarditis
AT tanabekazuaki asymptomaticimmunecheckpointinhibitorassociatedmyocarditis

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