Regression of Lung Squamous Cell Carcinoma after the Withdrawal of Cyclosporin A Combined with Pirfenidone Treatment in a Patient with Idiopathic Pulmonary Fibrosis

A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis. A nodule with a diameter of 19 mm was found in the right lung and diagnosed as lung squamous cell carcinoma. Anti-cancer treatments were not performed because of the presence of advanced interstitia...

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Detalles Bibliográficos
Autores principales: Takahashi, Mari, Horio, Yukihiro, Takihara, Takahisa, Enokida, Keito, Miyaoka, Masashi, Hirabayashi, Kenichi, Ohshinden, Kana, Hattori, Shigeaki, Takahashi, Fuminari, Takahashi, Genki, Tanaka, Jun, Takiguchi, Hiroto, Niimi, Kyoko, Ito, Yoko, Hayama, Naoki, Oguma, Tsuyoshi, Asano, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946518/
https://www.ncbi.nlm.nih.gov/pubmed/33028767
http://dx.doi.org/10.2169/internalmedicine.5125-20
Descripción
Sumario:A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis. A nodule with a diameter of 19 mm was found in the right lung and diagnosed as lung squamous cell carcinoma. Anti-cancer treatments were not performed because of the presence of advanced interstitial pneumonia and chronic respiratory failure. Cyclosporine A was tapered to avoid suppression of anti-tumor immunity, and pirfenidone was initiated. Within 2 months, the tumor had shrunk to 10 mm in diameter and remained regressed for 9 months. This is the first report of a non-hematologic solid organ tumor responding to the discontinuation of immunosuppressants.

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