Comment on “ILC1 drive intestinal epithelial and matrix remodeling”

Type 1 Innate lymphoid cells (ILC1) accumulate in the inflamed mucosa of patients with Crohn’s disease (CD) but their role in CD pathogenesis remains poorly known. In a recent issue of Nature materials, Jowett et al. (Nat. Mat. 2020) used a coculture model with intestinal organoids to show that ILC1...

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Autores principales: Hariss, Fatima, Meresse, Bertrand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946633/
https://www.ncbi.nlm.nih.gov/pubmed/33542491
http://dx.doi.org/10.1038/s41385-020-00360-9
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author Hariss, Fatima
Meresse, Bertrand
author_facet Hariss, Fatima
Meresse, Bertrand
author_sort Hariss, Fatima
collection PubMed
description Type 1 Innate lymphoid cells (ILC1) accumulate in the inflamed mucosa of patients with Crohn’s disease (CD) but their role in CD pathogenesis remains poorly known. In a recent issue of Nature materials, Jowett et al. (Nat. Mat. 2020) used a coculture model with intestinal organoids to show that ILC1 could promote intestinal epithelial growth and tissue remodeling through an unexpected mechanism that involves the transforming growth factor 1 (TGF-β1) and the metalloproteinase MMP9.
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spelling pubmed-79466332021-03-28 Comment on “ILC1 drive intestinal epithelial and matrix remodeling” Hariss, Fatima Meresse, Bertrand Mucosal Immunol Comment Type 1 Innate lymphoid cells (ILC1) accumulate in the inflamed mucosa of patients with Crohn’s disease (CD) but their role in CD pathogenesis remains poorly known. In a recent issue of Nature materials, Jowett et al. (Nat. Mat. 2020) used a coculture model with intestinal organoids to show that ILC1 could promote intestinal epithelial growth and tissue remodeling through an unexpected mechanism that involves the transforming growth factor 1 (TGF-β1) and the metalloproteinase MMP9. Nature Publishing Group US 2021-02-04 2021 /pmc/articles/PMC7946633/ /pubmed/33542491 http://dx.doi.org/10.1038/s41385-020-00360-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Hariss, Fatima
Meresse, Bertrand
Comment on “ILC1 drive intestinal epithelial and matrix remodeling”
title Comment on “ILC1 drive intestinal epithelial and matrix remodeling”
title_full Comment on “ILC1 drive intestinal epithelial and matrix remodeling”
title_fullStr Comment on “ILC1 drive intestinal epithelial and matrix remodeling”
title_full_unstemmed Comment on “ILC1 drive intestinal epithelial and matrix remodeling”
title_short Comment on “ILC1 drive intestinal epithelial and matrix remodeling”
title_sort comment on “ilc1 drive intestinal epithelial and matrix remodeling”
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946633/
https://www.ncbi.nlm.nih.gov/pubmed/33542491
http://dx.doi.org/10.1038/s41385-020-00360-9
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