Porcine model elucidates function of p53 isoform in carcinogenesis and reveals novel circTP53 RNA

Recent years have seen an increasing number of genetically engineered pig models of human diseases including cancer. We previously generated pigs with a modified TP53 allele that carries a Cre-removable transcriptional stop signal in intron 1, and an oncogenic mutation TP53(R167H) (orthologous to hu...

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Detalles Bibliográficos
Autores principales: Niu, Guanglin, Hellmuth, Isabel, Flisikowska, Tatiana, Pausch, Hubert, Rieblinger, Beate, Carrapeiro, Alexander, Schade, Benjamin, Böhm, Brigitte, Kappe, Eva, Fischer, Konrad, Klinger, Bernhard, Steiger, Katja, Burgkart, Reiner, Bourdon, Jean-Christophe, Saur, Dieter, Kind, Alexander, Schnieke, Angelika, Flisikowski, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946636/
https://www.ncbi.nlm.nih.gov/pubmed/33603167
http://dx.doi.org/10.1038/s41388-021-01686-9

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