Immortalization of Human Keratinocytes Using the Catalytic Subunit of Telomerase

A new stable line of human keratinocytes was obtained. The cells have altered morphology, both abnormal chromosomal composition and expression of keratinocyte markers, do not show contact inhibition, could be cultured in various media and have limited stratification ability in vitro. Upon transplant...

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Detalles Bibliográficos
Autores principales: Beilin, A. K., Gurskaya, N. G., Evtushenko, N. A., Alpeeva, E. V., Kosykh, A. V., Terskikh, V. V., Vasiliev, A. V., Vorotelyak, E. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2021
Materias:
Biochemistry, Biophysics, and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946653/
https://www.ncbi.nlm.nih.gov/pubmed/33689065
http://dx.doi.org/10.1134/S1607672921010014
Descripción
Sumario:A new stable line of human keratinocytes was obtained. The cells have altered morphology, both abnormal chromosomal composition and expression of keratinocyte markers, do not show contact inhibition, could be cultured in various media and have limited stratification ability in vitro. Upon transplantation into nude mice the cells have tumorigenic properties.

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