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Neural substrates of anorexia nervosa patient’s deficits to decode emotional information

PURPOSE: The aim of the study was to define specific substrates of pathological behaviour patterns by analysing cortical activity using functional magnetic resonance imaging (fMRI) during an emotional processing task. METHODS: In a sample of N = 11 adolescent patients with AN (16.36 years, SD ± 1.36...

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Autores principales: Lulé, Dorothée, Müller, Sabine, Fladung, Anne-Katharina, Uttner, Ingo, Schulze, Ulrike M. E .
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946662/
https://www.ncbi.nlm.nih.gov/pubmed/32358652
http://dx.doi.org/10.1007/s40519-020-00900-z
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author Lulé, Dorothée
Müller, Sabine
Fladung, Anne-Katharina
Uttner, Ingo
Schulze, Ulrike M. E .
author_facet Lulé, Dorothée
Müller, Sabine
Fladung, Anne-Katharina
Uttner, Ingo
Schulze, Ulrike M. E .
author_sort Lulé, Dorothée
collection PubMed
description PURPOSE: The aim of the study was to define specific substrates of pathological behaviour patterns by analysing cortical activity using functional magnetic resonance imaging (fMRI) during an emotional processing task. METHODS: In a sample of N = 11 adolescent patients with AN (16.36 years, SD ± 1.36) and N = 11 age-matched controls, we performed a functional MRI study to detect BOLD signal changes in a 3 T MRI scanner while presenting emotional facial stimuli. RESULTS: Young people with AN presented with a generally reduced cortical activation pattern in key areas of emotion recognition for happy and fearful faces. Areas essential for control of social behaviour were associated with symptoms of depression. CONCLUSION: Obviously, there are already indications of cortical patterns in young affected persons, which indicate a changed emotional reaction to potentially aversive stimuli in the sense of a changed top-down process of emotion avoidance. Thus, the current study provides further evidence that the disorder of anorexia nervosa is closely related to deficits in emotion processing in the early course of ontogenesis. Depressive symptoms might additionally trigger pathological behavior. Due to the small sample size, the data should be considered preliminary and require further validation. LEVEL OF EVIDENCE: Level of evidence III: case–control study.
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spelling pubmed-79466622021-03-28 Neural substrates of anorexia nervosa patient’s deficits to decode emotional information Lulé, Dorothée Müller, Sabine Fladung, Anne-Katharina Uttner, Ingo Schulze, Ulrike M. E . Eat Weight Disord Brief Report PURPOSE: The aim of the study was to define specific substrates of pathological behaviour patterns by analysing cortical activity using functional magnetic resonance imaging (fMRI) during an emotional processing task. METHODS: In a sample of N = 11 adolescent patients with AN (16.36 years, SD ± 1.36) and N = 11 age-matched controls, we performed a functional MRI study to detect BOLD signal changes in a 3 T MRI scanner while presenting emotional facial stimuli. RESULTS: Young people with AN presented with a generally reduced cortical activation pattern in key areas of emotion recognition for happy and fearful faces. Areas essential for control of social behaviour were associated with symptoms of depression. CONCLUSION: Obviously, there are already indications of cortical patterns in young affected persons, which indicate a changed emotional reaction to potentially aversive stimuli in the sense of a changed top-down process of emotion avoidance. Thus, the current study provides further evidence that the disorder of anorexia nervosa is closely related to deficits in emotion processing in the early course of ontogenesis. Depressive symptoms might additionally trigger pathological behavior. Due to the small sample size, the data should be considered preliminary and require further validation. LEVEL OF EVIDENCE: Level of evidence III: case–control study. Springer International Publishing 2020-05-01 2021 /pmc/articles/PMC7946662/ /pubmed/32358652 http://dx.doi.org/10.1007/s40519-020-00900-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Report
Lulé, Dorothée
Müller, Sabine
Fladung, Anne-Katharina
Uttner, Ingo
Schulze, Ulrike M. E .
Neural substrates of anorexia nervosa patient’s deficits to decode emotional information
title Neural substrates of anorexia nervosa patient’s deficits to decode emotional information
title_full Neural substrates of anorexia nervosa patient’s deficits to decode emotional information
title_fullStr Neural substrates of anorexia nervosa patient’s deficits to decode emotional information
title_full_unstemmed Neural substrates of anorexia nervosa patient’s deficits to decode emotional information
title_short Neural substrates of anorexia nervosa patient’s deficits to decode emotional information
title_sort neural substrates of anorexia nervosa patient’s deficits to decode emotional information
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946662/
https://www.ncbi.nlm.nih.gov/pubmed/32358652
http://dx.doi.org/10.1007/s40519-020-00900-z
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