Cargando…
In Nasal Mucosal Secretions, Distinct IFN and IgA Responses Are Found in Severe and Mild SARS-CoV-2 Infection
Likely as in other viral respiratory diseases, SARS-CoV-2 elicit a local immune response, which includes production and releasing of both cytokines and secretory immunoglobulin (SIgA). Therefore, in this study, we investigated the levels of specific-SIgA for SARS-CoV-2 and cytokines in the airways m...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946815/ https://www.ncbi.nlm.nih.gov/pubmed/33717074 http://dx.doi.org/10.3389/fimmu.2021.595343 |
_version_ | 1783663109320212480 |
---|---|
author | dos Santos, Juliana de Melo Batista Soares, Camila Pereira Monteiro, Fernanda Rodrigues Mello, Ralyria do Amaral, Jonatas Bussador Aguiar, Andressa Simões Soledade, Mariana Pereira Sucupira, Carolina De Paulis, Milena Andrade, Juliana Bannwart Almeida, Flavia Jaqueline Sáfadi, Marco Aurélio Palazzi Mau, Luciana Becker Brasil, Jamile Menezes Ramalho, Theresa Loures, Flávio V. Vieira, Rodolfo Paula Durigon, Edison Luiz de Oliveira, Danielle Bruna Leal Bachi, André Luis Lacerda |
author_facet | dos Santos, Juliana de Melo Batista Soares, Camila Pereira Monteiro, Fernanda Rodrigues Mello, Ralyria do Amaral, Jonatas Bussador Aguiar, Andressa Simões Soledade, Mariana Pereira Sucupira, Carolina De Paulis, Milena Andrade, Juliana Bannwart Almeida, Flavia Jaqueline Sáfadi, Marco Aurélio Palazzi Mau, Luciana Becker Brasil, Jamile Menezes Ramalho, Theresa Loures, Flávio V. Vieira, Rodolfo Paula Durigon, Edison Luiz de Oliveira, Danielle Bruna Leal Bachi, André Luis Lacerda |
author_sort | dos Santos, Juliana de Melo Batista |
collection | PubMed |
description | Likely as in other viral respiratory diseases, SARS-CoV-2 elicit a local immune response, which includes production and releasing of both cytokines and secretory immunoglobulin (SIgA). Therefore, in this study, we investigated the levels of specific-SIgA for SARS-CoV-2 and cytokines in the airways mucosa 37 patients who were suspected of COVID-19. According to the RT-PCR results, the patients were separated into three groups: negative for COVID-19 and other viruses (NEGS, n = 5); negative for COVID-19 but positive for the presence of other viruses (OTHERS, n = 5); and the positive for COVID-19 (COVID-19, n = 27). Higher specific-SIgA for SARS-CoV-2, IFN-β, and IFN-γ were found in the COVID-19 group than in the other groups. Increased IL-12p70 levels were observed in OTHERS group as compared to COVID-19 group. When the COVID-19 group was sub stratified according to the illness severity, significant differences and correlations were found for the same parameters described above comparing severe COVID-19 to the mild COVID-19 group and other non-COVID-19 groups. For the first time, significant differences are shown in the airway's mucosa immune responses in different groups of patients with or without respiratory SARS-CoV-2 infection. |
format | Online Article Text |
id | pubmed-7946815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79468152021-03-12 In Nasal Mucosal Secretions, Distinct IFN and IgA Responses Are Found in Severe and Mild SARS-CoV-2 Infection dos Santos, Juliana de Melo Batista Soares, Camila Pereira Monteiro, Fernanda Rodrigues Mello, Ralyria do Amaral, Jonatas Bussador Aguiar, Andressa Simões Soledade, Mariana Pereira Sucupira, Carolina De Paulis, Milena Andrade, Juliana Bannwart Almeida, Flavia Jaqueline Sáfadi, Marco Aurélio Palazzi Mau, Luciana Becker Brasil, Jamile Menezes Ramalho, Theresa Loures, Flávio V. Vieira, Rodolfo Paula Durigon, Edison Luiz de Oliveira, Danielle Bruna Leal Bachi, André Luis Lacerda Front Immunol Immunology Likely as in other viral respiratory diseases, SARS-CoV-2 elicit a local immune response, which includes production and releasing of both cytokines and secretory immunoglobulin (SIgA). Therefore, in this study, we investigated the levels of specific-SIgA for SARS-CoV-2 and cytokines in the airways mucosa 37 patients who were suspected of COVID-19. According to the RT-PCR results, the patients were separated into three groups: negative for COVID-19 and other viruses (NEGS, n = 5); negative for COVID-19 but positive for the presence of other viruses (OTHERS, n = 5); and the positive for COVID-19 (COVID-19, n = 27). Higher specific-SIgA for SARS-CoV-2, IFN-β, and IFN-γ were found in the COVID-19 group than in the other groups. Increased IL-12p70 levels were observed in OTHERS group as compared to COVID-19 group. When the COVID-19 group was sub stratified according to the illness severity, significant differences and correlations were found for the same parameters described above comparing severe COVID-19 to the mild COVID-19 group and other non-COVID-19 groups. For the first time, significant differences are shown in the airway's mucosa immune responses in different groups of patients with or without respiratory SARS-CoV-2 infection. Frontiers Media S.A. 2021-02-25 /pmc/articles/PMC7946815/ /pubmed/33717074 http://dx.doi.org/10.3389/fimmu.2021.595343 Text en Copyright © 2021 Santos, Soares, Monteiro, Mello, Amaral, Aguiar, Soledade, Sucupira, De Paulis, Andrade, Almeida, Sáfadi, Mau, Brasil, Ramalho, Loures, Vieira, Durigon, de Oliveira and Bachi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology dos Santos, Juliana de Melo Batista Soares, Camila Pereira Monteiro, Fernanda Rodrigues Mello, Ralyria do Amaral, Jonatas Bussador Aguiar, Andressa Simões Soledade, Mariana Pereira Sucupira, Carolina De Paulis, Milena Andrade, Juliana Bannwart Almeida, Flavia Jaqueline Sáfadi, Marco Aurélio Palazzi Mau, Luciana Becker Brasil, Jamile Menezes Ramalho, Theresa Loures, Flávio V. Vieira, Rodolfo Paula Durigon, Edison Luiz de Oliveira, Danielle Bruna Leal Bachi, André Luis Lacerda In Nasal Mucosal Secretions, Distinct IFN and IgA Responses Are Found in Severe and Mild SARS-CoV-2 Infection |
title | In Nasal Mucosal Secretions, Distinct IFN and IgA Responses Are Found in Severe and Mild SARS-CoV-2 Infection |
title_full | In Nasal Mucosal Secretions, Distinct IFN and IgA Responses Are Found in Severe and Mild SARS-CoV-2 Infection |
title_fullStr | In Nasal Mucosal Secretions, Distinct IFN and IgA Responses Are Found in Severe and Mild SARS-CoV-2 Infection |
title_full_unstemmed | In Nasal Mucosal Secretions, Distinct IFN and IgA Responses Are Found in Severe and Mild SARS-CoV-2 Infection |
title_short | In Nasal Mucosal Secretions, Distinct IFN and IgA Responses Are Found in Severe and Mild SARS-CoV-2 Infection |
title_sort | in nasal mucosal secretions, distinct ifn and iga responses are found in severe and mild sars-cov-2 infection |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946815/ https://www.ncbi.nlm.nih.gov/pubmed/33717074 http://dx.doi.org/10.3389/fimmu.2021.595343 |
work_keys_str_mv | AT dossantosjulianademelobatista innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT soarescamilapereira innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT monteirofernandarodrigues innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT melloralyria innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT doamaraljonatasbussador innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT aguiarandressasimoes innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT soledademarianapereira innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT sucupiracarolina innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT depaulismilena innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT andradejulianabannwart innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT almeidaflaviajaqueline innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT safadimarcoaureliopalazzi innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT maulucianabecker innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT brasiljamilemenezes innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT ramalhotheresa innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT louresflaviov innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT vieirarodolfopaula innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT durigonedisonluiz innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT deoliveiradaniellebrunaleal innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection AT bachiandreluislacerda innasalmucosalsecretionsdistinctifnandigaresponsesarefoundinsevereandmildsarscov2infection |