Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

An aberrant fusion of the DNAJB1 and PRKACA genes generates a chimeric protein kinase (PKA-C(DNAJB1)) in which the J-domain of the heat shock protein 40 is fused to the catalytic α subunit of cAMP-dependent protein kinase A (PKA-C). Deceivingly, this chimeric construct appears to be fully functional...

Descripción completa

Detalles Bibliográficos
Autores principales: Olivieri, Cristina, Walker, Caitlin, Karamafrooz, Adak, Wang, Yingjie, Manu, V. S., Porcelli, Fernando, Blumenthal, Donald K., Thomas, David D., Bernlohr, David A., Simon, Sanford M., Taylor, Susan S., Veglia, Gianluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946884/
https://www.ncbi.nlm.nih.gov/pubmed/33692454
http://dx.doi.org/10.1038/s42003-021-01819-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946884/
https://www.ncbi.nlm.nih.gov/pubmed/33692454
http://dx.doi.org/10.1038/s42003-021-01819-6

Ejemplares similares