The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites

The differentiation of human blood monocytes (MO), the post-mitotic precursors of macrophages (MAC) and dendritic cells (moDC), is accompanied by the active turnover of DNA methylation, but the extent, consequences and mechanisms of DNA methylation changes remain unclear. Here, we profile and compar...

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Detalles Bibliográficos
Autores principales: Mendes, Karina, Schmidhofer, Sandra, Minderjahn, Julia, Glatz, Dagmar, Kiesewetter, Claudia, Raithel, Johanna, Wimmer, Julia, Gebhard, Claudia, Rehli, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946903/
https://www.ncbi.nlm.nih.gov/pubmed/33692344
http://dx.doi.org/10.1038/s41467-021-21661-y

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