Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

The lipid phosphatidylinositol-3-phosphate (PI3P) is a regulator of two fundamental but distinct cellular processes, endocytosis and autophagy, so its generation needs to be under precise temporal and spatial control. PI3P is generated by two complexes that both contain the lipid kinase VPS34: compl...

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Detalles Bibliográficos
Autores principales: Tremel, Shirley, Ohashi, Yohei, Morado, Dustin R., Bertram, Jessie, Perisic, Olga, Brandt, Laura T. L., von Wrisberg, Marie-Kristin, Chen, Zhuo A., Maslen, Sarah L., Kovtun, Oleksiy, Skehel, Mark, Rappsilber, Juri, Lang, Kathrin, Munro, Sean, Briggs, John A. G., Williams, Roger L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946940/
https://www.ncbi.nlm.nih.gov/pubmed/33692360
http://dx.doi.org/10.1038/s41467-021-21695-2

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