Cargando…
Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation
The ULK complex initiates the autophagosome formation, and has recently been implicated in selective autophagy by interacting with autophagy receptors through its FIP200 subunit. However, the structural mechanism underlying the interactions of autophagy receptors with FIP200 and the relevant regulat...
Autores principales: | Zhou, Zixuan, Liu, Jianping, Fu, Tao, Wu, Ping, Peng, Chao, Gong, Xinyu, Wang, Yingli, Zhang, Mingfang, Li, Ying, Wang, Yaru, Xu, Xiaolong, Li, Miao, Pan, Lifeng |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946963/ https://www.ncbi.nlm.nih.gov/pubmed/33692357 http://dx.doi.org/10.1038/s41467-021-21874-1 |
Ejemplares similares
-
Structural and biochemical advances on the recruitment of the autophagy-initiating ULK and TBK1 complexes by autophagy receptor NDP52
por: Fu, Tao, et al.
Publicado: (2021) -
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates
por: Turco, Eleonora, et al.
Publicado: (2019) -
ATG16L1 adopts a dual–binding site mode to interact with WIPI2b in autophagy
por: Gong, Xinyu, et al.
Publicado: (2023) -
ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer
por: Shi, Xiaoshan, et al.
Publicado: (2020) -
FIP200 Methylation by SETD2 Prevents Trim21-Induced Degradation and Preserves Autophagy Initiation
por: Dai, Yuan, et al.
Publicado: (2022)