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LRIG3 Suppresses Angiogenesis by Regulating the PI3K/AKT/VEGFA Signaling Pathway in Glioma
High levels of microvessel density (MVD) indicate poor prognosis in patients with malignant glioma. Leucine-rich repeats and immunoglobulin-like domains (LRIG) 3, a potential tumor suppressor, plays an important role in tumor progression and may serve as a biomarker in many human cancers. However, i...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946980/ https://www.ncbi.nlm.nih.gov/pubmed/33718179 http://dx.doi.org/10.3389/fonc.2021.621154 |
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author | Peng, Chenghao Chen, Hanmin Li, Youwei Yang, Hang Qin, Peizhong Ma, Baojun Duan, Qiuhong Wang, Baofeng Mao, Feng Guo, Dongsheng |
author_facet | Peng, Chenghao Chen, Hanmin Li, Youwei Yang, Hang Qin, Peizhong Ma, Baojun Duan, Qiuhong Wang, Baofeng Mao, Feng Guo, Dongsheng |
author_sort | Peng, Chenghao |
collection | PubMed |
description | High levels of microvessel density (MVD) indicate poor prognosis in patients with malignant glioma. Leucine-rich repeats and immunoglobulin-like domains (LRIG) 3, a potential tumor suppressor, plays an important role in tumor progression and may serve as a biomarker in many human cancers. However, its role and underlying mechanism of action in glioma angiogenesis remain unclear. In the present study, we used loss- and gain-of-function assays to show that LRIG3 significantly suppressed glioma-induced angiogenesis, both in vitro and in vivo. Mechanistically, LRIG3 inhibited activation of the PI3K/AKT signaling pathway, downregulating vascular endothelial growth factor A (VEGFA) in glioma cells, thereby inhibiting angiogenesis. Notably, LRIG3 had a significant negative correlation with VEGFA expression in glioma tissues. Taken together, our results suggest that LRIG3 is a novel regulator of glioma angiogenesis and may be a promising option for developing anti-angiogenic therapy. |
format | Online Article Text |
id | pubmed-7946980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79469802021-03-12 LRIG3 Suppresses Angiogenesis by Regulating the PI3K/AKT/VEGFA Signaling Pathway in Glioma Peng, Chenghao Chen, Hanmin Li, Youwei Yang, Hang Qin, Peizhong Ma, Baojun Duan, Qiuhong Wang, Baofeng Mao, Feng Guo, Dongsheng Front Oncol Oncology High levels of microvessel density (MVD) indicate poor prognosis in patients with malignant glioma. Leucine-rich repeats and immunoglobulin-like domains (LRIG) 3, a potential tumor suppressor, plays an important role in tumor progression and may serve as a biomarker in many human cancers. However, its role and underlying mechanism of action in glioma angiogenesis remain unclear. In the present study, we used loss- and gain-of-function assays to show that LRIG3 significantly suppressed glioma-induced angiogenesis, both in vitro and in vivo. Mechanistically, LRIG3 inhibited activation of the PI3K/AKT signaling pathway, downregulating vascular endothelial growth factor A (VEGFA) in glioma cells, thereby inhibiting angiogenesis. Notably, LRIG3 had a significant negative correlation with VEGFA expression in glioma tissues. Taken together, our results suggest that LRIG3 is a novel regulator of glioma angiogenesis and may be a promising option for developing anti-angiogenic therapy. Frontiers Media S.A. 2021-02-25 /pmc/articles/PMC7946980/ /pubmed/33718179 http://dx.doi.org/10.3389/fonc.2021.621154 Text en Copyright © 2021 Peng, Chen, Li, Yang, Qin, Ma, Duan, Wang, Mao and Guo http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Peng, Chenghao Chen, Hanmin Li, Youwei Yang, Hang Qin, Peizhong Ma, Baojun Duan, Qiuhong Wang, Baofeng Mao, Feng Guo, Dongsheng LRIG3 Suppresses Angiogenesis by Regulating the PI3K/AKT/VEGFA Signaling Pathway in Glioma |
title | LRIG3 Suppresses Angiogenesis by Regulating the PI3K/AKT/VEGFA Signaling Pathway in Glioma |
title_full | LRIG3 Suppresses Angiogenesis by Regulating the PI3K/AKT/VEGFA Signaling Pathway in Glioma |
title_fullStr | LRIG3 Suppresses Angiogenesis by Regulating the PI3K/AKT/VEGFA Signaling Pathway in Glioma |
title_full_unstemmed | LRIG3 Suppresses Angiogenesis by Regulating the PI3K/AKT/VEGFA Signaling Pathway in Glioma |
title_short | LRIG3 Suppresses Angiogenesis by Regulating the PI3K/AKT/VEGFA Signaling Pathway in Glioma |
title_sort | lrig3 suppresses angiogenesis by regulating the pi3k/akt/vegfa signaling pathway in glioma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946980/ https://www.ncbi.nlm.nih.gov/pubmed/33718179 http://dx.doi.org/10.3389/fonc.2021.621154 |
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