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Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer

Alpha-fetoprotein (AFP) entrance into cancer cells is mediated by AFP receptors (AFPRs) and exerts malignant effects. Therefore, understanding the structure of AFPRs will facilitate the development of rational approaches for vaccine design, drug delivery, antagonizing immune suppression and diagnost...

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Detalles Bibliográficos
Autores principales: Lin, Bo, Wang, Qiujiao, Liu, Kun, Dong, Xu, Zhu, Mingyue, Li, Mengsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947232/
https://www.ncbi.nlm.nih.gov/pubmed/33718192
http://dx.doi.org/10.3389/fonc.2021.625936
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author Lin, Bo
Wang, Qiujiao
Liu, Kun
Dong, Xu
Zhu, Mingyue
Li, Mengsen
author_facet Lin, Bo
Wang, Qiujiao
Liu, Kun
Dong, Xu
Zhu, Mingyue
Li, Mengsen
author_sort Lin, Bo
collection PubMed
description Alpha-fetoprotein (AFP) entrance into cancer cells is mediated by AFP receptors (AFPRs) and exerts malignant effects. Therefore, understanding the structure of AFPRs will facilitate the development of rational approaches for vaccine design, drug delivery, antagonizing immune suppression and diagnostic imaging to treat cancer effectively. Throughout the last three decades, the identification of universal receptors for AFP has failed due to their complex carbohydrate polymer structures. Here, we focused on the two types of binding proteins or receptors that may serve as AFPRs, namely, the A) mucin receptors family, and B) the scavenger family. We presented an informative review with detailed descriptions of the signal transduction, cross-talk, and interplay of various transcription factors which highlight the downstream events following AFP binding to mucin or scavenger receptors. We mainly explored the underlying mechanisms involved mucin or scavenger receptors that interact with AFP, provide more evidence to support these receptors as tumor AFPRs, and establish a theoretical basis for targeting therapy of cancer.
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spelling pubmed-79472322021-03-12 Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer Lin, Bo Wang, Qiujiao Liu, Kun Dong, Xu Zhu, Mingyue Li, Mengsen Front Oncol Oncology Alpha-fetoprotein (AFP) entrance into cancer cells is mediated by AFP receptors (AFPRs) and exerts malignant effects. Therefore, understanding the structure of AFPRs will facilitate the development of rational approaches for vaccine design, drug delivery, antagonizing immune suppression and diagnostic imaging to treat cancer effectively. Throughout the last three decades, the identification of universal receptors for AFP has failed due to their complex carbohydrate polymer structures. Here, we focused on the two types of binding proteins or receptors that may serve as AFPRs, namely, the A) mucin receptors family, and B) the scavenger family. We presented an informative review with detailed descriptions of the signal transduction, cross-talk, and interplay of various transcription factors which highlight the downstream events following AFP binding to mucin or scavenger receptors. We mainly explored the underlying mechanisms involved mucin or scavenger receptors that interact with AFP, provide more evidence to support these receptors as tumor AFPRs, and establish a theoretical basis for targeting therapy of cancer. Frontiers Media S.A. 2021-02-25 /pmc/articles/PMC7947232/ /pubmed/33718192 http://dx.doi.org/10.3389/fonc.2021.625936 Text en Copyright © 2021 Lin, Wang, Liu, Dong, Zhu and Li http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lin, Bo
Wang, Qiujiao
Liu, Kun
Dong, Xu
Zhu, Mingyue
Li, Mengsen
Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer
title Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer
title_full Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer
title_fullStr Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer
title_full_unstemmed Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer
title_short Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer
title_sort alpha-fetoprotein binding mucin and scavenger receptors: an available bio-target for treating cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947232/
https://www.ncbi.nlm.nih.gov/pubmed/33718192
http://dx.doi.org/10.3389/fonc.2021.625936
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