Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases

A regulator of ribosome synthesis 1 (RRS1) was discovered in yeast and is mainly localized in the nucleolus and endoplasmic reticulum. It regulates ribosomal protein, RNA biosynthesis, and protein secretion and is closely involved in cellular senescence, cell cycle regulation, transcription, transla...

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Autores principales: Hua, Yanan, Song, Jinlian, Peng, Cuixiu, Wang, Runze, Ma, Zhongliang, Zhang, Jinyu, Zhang, Zheng, Li, Ning, Hou, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947238/
https://www.ncbi.nlm.nih.gov/pubmed/33718361
http://dx.doi.org/10.3389/fcell.2021.620925
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author Hua, Yanan
Song, Jinlian
Peng, Cuixiu
Wang, Runze
Ma, Zhongliang
Zhang, Jinyu
Zhang, Zheng
Li, Ning
Hou, Lin
author_facet Hua, Yanan
Song, Jinlian
Peng, Cuixiu
Wang, Runze
Ma, Zhongliang
Zhang, Jinyu
Zhang, Zheng
Li, Ning
Hou, Lin
author_sort Hua, Yanan
collection PubMed
description A regulator of ribosome synthesis 1 (RRS1) was discovered in yeast and is mainly localized in the nucleolus and endoplasmic reticulum. It regulates ribosomal protein, RNA biosynthesis, and protein secretion and is closely involved in cellular senescence, cell cycle regulation, transcription, translation, oncogenic transformation etc., Mutations in the RRS1 gene are associated with the occurrence and development of Huntington’s disease and cancer, and overexpression of RRS1 promotes tumor growth and metastasis. In this review, the structure, function, and mechanisms of RRS1 in various diseases are discussed.
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spelling pubmed-79472382021-03-12 Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases Hua, Yanan Song, Jinlian Peng, Cuixiu Wang, Runze Ma, Zhongliang Zhang, Jinyu Zhang, Zheng Li, Ning Hou, Lin Front Cell Dev Biol Cell and Developmental Biology A regulator of ribosome synthesis 1 (RRS1) was discovered in yeast and is mainly localized in the nucleolus and endoplasmic reticulum. It regulates ribosomal protein, RNA biosynthesis, and protein secretion and is closely involved in cellular senescence, cell cycle regulation, transcription, translation, oncogenic transformation etc., Mutations in the RRS1 gene are associated with the occurrence and development of Huntington’s disease and cancer, and overexpression of RRS1 promotes tumor growth and metastasis. In this review, the structure, function, and mechanisms of RRS1 in various diseases are discussed. Frontiers Media S.A. 2021-02-25 /pmc/articles/PMC7947238/ /pubmed/33718361 http://dx.doi.org/10.3389/fcell.2021.620925 Text en Copyright © 2021 Hua, Song, Peng, Wang, Ma, Zhang, Zhang, Li and Hou. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Hua, Yanan
Song, Jinlian
Peng, Cuixiu
Wang, Runze
Ma, Zhongliang
Zhang, Jinyu
Zhang, Zheng
Li, Ning
Hou, Lin
Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases
title Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases
title_full Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases
title_fullStr Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases
title_full_unstemmed Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases
title_short Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases
title_sort advances in the relationship between regulator of ribosome synthesis 1 (rrs1) and diseases
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947238/
https://www.ncbi.nlm.nih.gov/pubmed/33718361
http://dx.doi.org/10.3389/fcell.2021.620925
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