Cargando…
Genetic Parameters and Genome-Wide Association Studies of Eight Longevity Traits Representing Either Full or Partial Lifespan in Chinese Holsteins
Due to the complexity of longevity trait in dairy cattle, two groups of trait definitions are widely used to measure longevity, either covering the full lifespan or representing only a part of it to achieve an early selection. Usually, only one group of longevity definition is used in breeding progr...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947242/ https://www.ncbi.nlm.nih.gov/pubmed/33719343 http://dx.doi.org/10.3389/fgene.2021.634986 |
_version_ | 1783663181484261376 |
---|---|
author | Zhang, Hailiang Liu, Aoxing Wang, Yachun Luo, Hanpeng Yan, Xinyi Guo, Xiangyu Li, Xiang Liu, Lin Su, Guosheng |
author_facet | Zhang, Hailiang Liu, Aoxing Wang, Yachun Luo, Hanpeng Yan, Xinyi Guo, Xiangyu Li, Xiang Liu, Lin Su, Guosheng |
author_sort | Zhang, Hailiang |
collection | PubMed |
description | Due to the complexity of longevity trait in dairy cattle, two groups of trait definitions are widely used to measure longevity, either covering the full lifespan or representing only a part of it to achieve an early selection. Usually, only one group of longevity definition is used in breeding program for one population, and genetic studies on the comparisons of two groups of trait definitions are scarce. Based on the data of eight traits well representing the both groups of trait definitions, the current study investigated genetic parameters and genetic architectures of longevity in Holsteins. Heritabilities and correlations of eight longevity traits were estimated using single-trait and multi-trait animal models, with the data from 103,479 cows. Among the cows with phenotypes, 2,630 cows were genotyped with the 150K-SNP panel. A single-trait fixed and random Circuitous Probability Unification model was performed to detect candidate genes for eight longevity traits. Generally, all eight longevity traits had low heritabilities, ranging from 0.038 for total productive life and herd life to 0.090 for days from the first calving to the end of first lactation or culling. High genetic correlations were observed among the traits within the same definition group: from 0.946 to 0.997 for three traits reflecting full lifespan and from 0.666 to 0.997 for five traits reflecting partial productive life. Genetic correlations between two groups of traits ranged from 0.648 to 0.963, and increased gradually with the extension of lactations number regarding the partial productive life traits. A total of 55 SNPs located on 25 chromosomes were found genome-wide significantly associated with longevity, in which 12 SNPs were associated with more than one trait, even across traits of different definition groups. This is the first study to investigate the genetic architecture of longevity representing both full and the partial lifespan simultaneously, which will assist the selection of an appropriate trait definition for genetic improvement of longevity. Because of high genetic correlations with the full lifespan traits and higher heritability, the partial productive life trait measured as the days from the first calving to the end of the third lactation or culling could be a good alternative for early selection on longevity. The candidate genes identified by this study, such as RPRM, GRIA3, GTF2H5, CA5A, CACNA2D1, FGF10, and DNAJA3, could be used to pinpoint causative mutations for longevity and further benefit the genomic improvement of longevity in dairy cattle. |
format | Online Article Text |
id | pubmed-7947242 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79472422021-03-12 Genetic Parameters and Genome-Wide Association Studies of Eight Longevity Traits Representing Either Full or Partial Lifespan in Chinese Holsteins Zhang, Hailiang Liu, Aoxing Wang, Yachun Luo, Hanpeng Yan, Xinyi Guo, Xiangyu Li, Xiang Liu, Lin Su, Guosheng Front Genet Genetics Due to the complexity of longevity trait in dairy cattle, two groups of trait definitions are widely used to measure longevity, either covering the full lifespan or representing only a part of it to achieve an early selection. Usually, only one group of longevity definition is used in breeding program for one population, and genetic studies on the comparisons of two groups of trait definitions are scarce. Based on the data of eight traits well representing the both groups of trait definitions, the current study investigated genetic parameters and genetic architectures of longevity in Holsteins. Heritabilities and correlations of eight longevity traits were estimated using single-trait and multi-trait animal models, with the data from 103,479 cows. Among the cows with phenotypes, 2,630 cows were genotyped with the 150K-SNP panel. A single-trait fixed and random Circuitous Probability Unification model was performed to detect candidate genes for eight longevity traits. Generally, all eight longevity traits had low heritabilities, ranging from 0.038 for total productive life and herd life to 0.090 for days from the first calving to the end of first lactation or culling. High genetic correlations were observed among the traits within the same definition group: from 0.946 to 0.997 for three traits reflecting full lifespan and from 0.666 to 0.997 for five traits reflecting partial productive life. Genetic correlations between two groups of traits ranged from 0.648 to 0.963, and increased gradually with the extension of lactations number regarding the partial productive life traits. A total of 55 SNPs located on 25 chromosomes were found genome-wide significantly associated with longevity, in which 12 SNPs were associated with more than one trait, even across traits of different definition groups. This is the first study to investigate the genetic architecture of longevity representing both full and the partial lifespan simultaneously, which will assist the selection of an appropriate trait definition for genetic improvement of longevity. Because of high genetic correlations with the full lifespan traits and higher heritability, the partial productive life trait measured as the days from the first calving to the end of the third lactation or culling could be a good alternative for early selection on longevity. The candidate genes identified by this study, such as RPRM, GRIA3, GTF2H5, CA5A, CACNA2D1, FGF10, and DNAJA3, could be used to pinpoint causative mutations for longevity and further benefit the genomic improvement of longevity in dairy cattle. Frontiers Media S.A. 2021-02-25 /pmc/articles/PMC7947242/ /pubmed/33719343 http://dx.doi.org/10.3389/fgene.2021.634986 Text en Copyright © 2021 Zhang, Liu, Wang, Luo, Yan, Guo, Li, Liu and Su. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Zhang, Hailiang Liu, Aoxing Wang, Yachun Luo, Hanpeng Yan, Xinyi Guo, Xiangyu Li, Xiang Liu, Lin Su, Guosheng Genetic Parameters and Genome-Wide Association Studies of Eight Longevity Traits Representing Either Full or Partial Lifespan in Chinese Holsteins |
title | Genetic Parameters and Genome-Wide Association Studies of Eight Longevity Traits Representing Either Full or Partial Lifespan in Chinese Holsteins |
title_full | Genetic Parameters and Genome-Wide Association Studies of Eight Longevity Traits Representing Either Full or Partial Lifespan in Chinese Holsteins |
title_fullStr | Genetic Parameters and Genome-Wide Association Studies of Eight Longevity Traits Representing Either Full or Partial Lifespan in Chinese Holsteins |
title_full_unstemmed | Genetic Parameters and Genome-Wide Association Studies of Eight Longevity Traits Representing Either Full or Partial Lifespan in Chinese Holsteins |
title_short | Genetic Parameters and Genome-Wide Association Studies of Eight Longevity Traits Representing Either Full or Partial Lifespan in Chinese Holsteins |
title_sort | genetic parameters and genome-wide association studies of eight longevity traits representing either full or partial lifespan in chinese holsteins |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947242/ https://www.ncbi.nlm.nih.gov/pubmed/33719343 http://dx.doi.org/10.3389/fgene.2021.634986 |
work_keys_str_mv | AT zhanghailiang geneticparametersandgenomewideassociationstudiesofeightlongevitytraitsrepresentingeitherfullorpartiallifespaninchineseholsteins AT liuaoxing geneticparametersandgenomewideassociationstudiesofeightlongevitytraitsrepresentingeitherfullorpartiallifespaninchineseholsteins AT wangyachun geneticparametersandgenomewideassociationstudiesofeightlongevitytraitsrepresentingeitherfullorpartiallifespaninchineseholsteins AT luohanpeng geneticparametersandgenomewideassociationstudiesofeightlongevitytraitsrepresentingeitherfullorpartiallifespaninchineseholsteins AT yanxinyi geneticparametersandgenomewideassociationstudiesofeightlongevitytraitsrepresentingeitherfullorpartiallifespaninchineseholsteins AT guoxiangyu geneticparametersandgenomewideassociationstudiesofeightlongevitytraitsrepresentingeitherfullorpartiallifespaninchineseholsteins AT lixiang geneticparametersandgenomewideassociationstudiesofeightlongevitytraitsrepresentingeitherfullorpartiallifespaninchineseholsteins AT liulin geneticparametersandgenomewideassociationstudiesofeightlongevitytraitsrepresentingeitherfullorpartiallifespaninchineseholsteins AT suguosheng geneticparametersandgenomewideassociationstudiesofeightlongevitytraitsrepresentingeitherfullorpartiallifespaninchineseholsteins |