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Scar-Free Healing of Endometrium: Tissue-Specific Program of Stromal Cells and Its Induction by Soluble Factors Produced After Damage

Besides certain exceptions, healing of most tissues in the human body occurs via formation of scar tissue, rather than restoration of lost structures. After extensive acute injuries, this phenomenon substantially limits the possibility of lost function recovery and, in case of chronic injury, it lea...

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Autores principales: Eremichev, Roman, Kulebyakina, Maria, Alexandrushkina, Nataliya, Nimiritsky, Peter, Basalova, Nataliya, Grigorieva, Olga, Egiazaryan, Mane, Dyikanov, Daniyar, Tkachuk, Vsevolod, Makarevich, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947248/
https://www.ncbi.nlm.nih.gov/pubmed/33718358
http://dx.doi.org/10.3389/fcell.2021.616893
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author Eremichev, Roman
Kulebyakina, Maria
Alexandrushkina, Nataliya
Nimiritsky, Peter
Basalova, Nataliya
Grigorieva, Olga
Egiazaryan, Mane
Dyikanov, Daniyar
Tkachuk, Vsevolod
Makarevich, Pavel
author_facet Eremichev, Roman
Kulebyakina, Maria
Alexandrushkina, Nataliya
Nimiritsky, Peter
Basalova, Nataliya
Grigorieva, Olga
Egiazaryan, Mane
Dyikanov, Daniyar
Tkachuk, Vsevolod
Makarevich, Pavel
author_sort Eremichev, Roman
collection PubMed
description Besides certain exceptions, healing of most tissues in the human body occurs via formation of scar tissue, rather than restoration of lost structures. After extensive acute injuries, this phenomenon substantially limits the possibility of lost function recovery and, in case of chronic injury, it leads to pathological remodeling of organs affected. Managing outcomes of damaged tissue repair is one of the main objectives of regenerative medicine. The first priority for reaching it is comparative investigation of mechanisms responsible for complete restoration of damaged tissues and mechanisms of scarring. However, human body tissues that undergo complete scar-free healing are scarce. The endometrium is a unique mucous membrane in the human body that heals without scarring after various injuries, as well as during each menstrual cycle (i.e., up to 400 times during a woman’s life). We hypothesized that absence of scarring during endometrial healing may be associated with tissue-specific features of its stromal cells (SCs) or their microenvironment, since SCs transform into myofibroblasts—the main effector link of scarring. We found that during healing of the endometrium, soluble factors are formed that inhibit the transition of SCs into myofibroblasts. Without influence of these factors, the SCs of the endometrium undergo transformation into myofibroblasts after transforming growth factor β1 (TGF-β1) treatment as well as the SCs from tissues that heal by scarring—skin or fat. However, unlike the latter, endometrial SCs organize extracellular matrix (ECM) in a specific way and are not prone to formation of bulky connective tissue structures. Thus, we may suggest that tissue-specific features of endometrial SCs along with effects of soluble factors secreted in utero during menstruation ensure scar-free healing of human endometrium.
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spelling pubmed-79472482021-03-12 Scar-Free Healing of Endometrium: Tissue-Specific Program of Stromal Cells and Its Induction by Soluble Factors Produced After Damage Eremichev, Roman Kulebyakina, Maria Alexandrushkina, Nataliya Nimiritsky, Peter Basalova, Nataliya Grigorieva, Olga Egiazaryan, Mane Dyikanov, Daniyar Tkachuk, Vsevolod Makarevich, Pavel Front Cell Dev Biol Cell and Developmental Biology Besides certain exceptions, healing of most tissues in the human body occurs via formation of scar tissue, rather than restoration of lost structures. After extensive acute injuries, this phenomenon substantially limits the possibility of lost function recovery and, in case of chronic injury, it leads to pathological remodeling of organs affected. Managing outcomes of damaged tissue repair is one of the main objectives of regenerative medicine. The first priority for reaching it is comparative investigation of mechanisms responsible for complete restoration of damaged tissues and mechanisms of scarring. However, human body tissues that undergo complete scar-free healing are scarce. The endometrium is a unique mucous membrane in the human body that heals without scarring after various injuries, as well as during each menstrual cycle (i.e., up to 400 times during a woman’s life). We hypothesized that absence of scarring during endometrial healing may be associated with tissue-specific features of its stromal cells (SCs) or their microenvironment, since SCs transform into myofibroblasts—the main effector link of scarring. We found that during healing of the endometrium, soluble factors are formed that inhibit the transition of SCs into myofibroblasts. Without influence of these factors, the SCs of the endometrium undergo transformation into myofibroblasts after transforming growth factor β1 (TGF-β1) treatment as well as the SCs from tissues that heal by scarring—skin or fat. However, unlike the latter, endometrial SCs organize extracellular matrix (ECM) in a specific way and are not prone to formation of bulky connective tissue structures. Thus, we may suggest that tissue-specific features of endometrial SCs along with effects of soluble factors secreted in utero during menstruation ensure scar-free healing of human endometrium. Frontiers Media S.A. 2021-02-25 /pmc/articles/PMC7947248/ /pubmed/33718358 http://dx.doi.org/10.3389/fcell.2021.616893 Text en Copyright © 2021 Eremichev, Kulebyakina, Alexandrushkina, Nimiritsky, Basalova, Grigorieva, Egiazaryan, Dyikanov, Tkachuk and Makarevich. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Eremichev, Roman
Kulebyakina, Maria
Alexandrushkina, Nataliya
Nimiritsky, Peter
Basalova, Nataliya
Grigorieva, Olga
Egiazaryan, Mane
Dyikanov, Daniyar
Tkachuk, Vsevolod
Makarevich, Pavel
Scar-Free Healing of Endometrium: Tissue-Specific Program of Stromal Cells and Its Induction by Soluble Factors Produced After Damage
title Scar-Free Healing of Endometrium: Tissue-Specific Program of Stromal Cells and Its Induction by Soluble Factors Produced After Damage
title_full Scar-Free Healing of Endometrium: Tissue-Specific Program of Stromal Cells and Its Induction by Soluble Factors Produced After Damage
title_fullStr Scar-Free Healing of Endometrium: Tissue-Specific Program of Stromal Cells and Its Induction by Soluble Factors Produced After Damage
title_full_unstemmed Scar-Free Healing of Endometrium: Tissue-Specific Program of Stromal Cells and Its Induction by Soluble Factors Produced After Damage
title_short Scar-Free Healing of Endometrium: Tissue-Specific Program of Stromal Cells and Its Induction by Soluble Factors Produced After Damage
title_sort scar-free healing of endometrium: tissue-specific program of stromal cells and its induction by soluble factors produced after damage
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947248/
https://www.ncbi.nlm.nih.gov/pubmed/33718358
http://dx.doi.org/10.3389/fcell.2021.616893
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