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Rationally Designed Bicyclic Peptides Prevent the Conversion of Aβ42 Assemblies Into Fibrillar Structures

There is great interest in drug discovery programs targeted at the aggregation of the 42-residue form of the amyloid β peptide (Aβ42), since this molecular process is closely associated with Alzheimer’s disease. The use of bicyclic peptides may offer novel opportunities for the effective modificatio...

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Detalles Bibliográficos
Autores principales:	Ikenoue, Tatsuya, Aprile, Francesco A., Sormanni, Pietro, Vendruscolo, Michele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947257/ https://www.ncbi.nlm.nih.gov/pubmed/33716651 http://dx.doi.org/10.3389/fnins.2021.623097

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