Cargando…

Preoperative peripheral blood neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratio (PLR) related nomograms predict the survival of patients with limited-stage small-cell lung cancer

BACKGROUND: We aim to establish neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) related nomograms based on the clinical data and peripheral blood markers to predict the survivals of patients with limited-stage small-cell lung cancer (LS-SCLC). METHODS: A total of 299 LS-S...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Chunji, Yang, Haitang, Cai, Deng, Xiang, Lujie, Fang, Wentao, Wang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947425/
https://www.ncbi.nlm.nih.gov/pubmed/33718028
http://dx.doi.org/10.21037/tlcr-20-997
_version_ 1783663224207441920
author Chen, Chunji
Yang, Haitang
Cai, Deng
Xiang, Lujie
Fang, Wentao
Wang, Rui
author_facet Chen, Chunji
Yang, Haitang
Cai, Deng
Xiang, Lujie
Fang, Wentao
Wang, Rui
author_sort Chen, Chunji
collection PubMed
description BACKGROUND: We aim to establish neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) related nomograms based on the clinical data and peripheral blood markers to predict the survivals of patients with limited-stage small-cell lung cancer (LS-SCLC). METHODS: A total of 299 LS-SCLC patients after surgery were enrolled in this study. Univariate and multivariate analyses were conducted to select independent prognostic factors to develop the nomograms and then subjected to bootstrap internal validation. The optimal cutoff value of NLR and PLR before surgery was calculated by X-tile (version 3.6.1) and the overall survival (OS) was analyzed by Kaplan-Meier method and compared by log-rank test. RESULTS: According to the X-tile calculation, the NLR value and PLR cutoff values are 2.6 and 156.7, respectively. The prognosis of patients with elevated NLR or PLR value was significantly worse than patients with lower NLR (HR =1.798, 95% CI: 1.284–2.518, P=0.001) or PLR (HR =1.781, 95% CI: 1.318–2.407, P<0.001) value. Two Nomograms were developed according to the two multivariate cox regression models based on NLR and PLR. Concordance index (C-index) curves and calibration curves show that the two models have a better effect in predicting prognosis. At the same time, compared with the tumor node metastasis (TNM) staging system, our models also show better accuracy and stability. CONCLUSIONS: Elevated NLR and PLR predict poor prognosis in their respective nomograms in patients with LS-SCLC.
format Online
Article
Text
id pubmed-7947425
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher AME Publishing Company
record_format MEDLINE/PubMed
spelling pubmed-79474252021-03-12 Preoperative peripheral blood neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratio (PLR) related nomograms predict the survival of patients with limited-stage small-cell lung cancer Chen, Chunji Yang, Haitang Cai, Deng Xiang, Lujie Fang, Wentao Wang, Rui Transl Lung Cancer Res Original Article BACKGROUND: We aim to establish neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) related nomograms based on the clinical data and peripheral blood markers to predict the survivals of patients with limited-stage small-cell lung cancer (LS-SCLC). METHODS: A total of 299 LS-SCLC patients after surgery were enrolled in this study. Univariate and multivariate analyses were conducted to select independent prognostic factors to develop the nomograms and then subjected to bootstrap internal validation. The optimal cutoff value of NLR and PLR before surgery was calculated by X-tile (version 3.6.1) and the overall survival (OS) was analyzed by Kaplan-Meier method and compared by log-rank test. RESULTS: According to the X-tile calculation, the NLR value and PLR cutoff values are 2.6 and 156.7, respectively. The prognosis of patients with elevated NLR or PLR value was significantly worse than patients with lower NLR (HR =1.798, 95% CI: 1.284–2.518, P=0.001) or PLR (HR =1.781, 95% CI: 1.318–2.407, P<0.001) value. Two Nomograms were developed according to the two multivariate cox regression models based on NLR and PLR. Concordance index (C-index) curves and calibration curves show that the two models have a better effect in predicting prognosis. At the same time, compared with the tumor node metastasis (TNM) staging system, our models also show better accuracy and stability. CONCLUSIONS: Elevated NLR and PLR predict poor prognosis in their respective nomograms in patients with LS-SCLC. AME Publishing Company 2021-02 /pmc/articles/PMC7947425/ /pubmed/33718028 http://dx.doi.org/10.21037/tlcr-20-997 Text en 2021 Translational Lung Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Chen, Chunji
Yang, Haitang
Cai, Deng
Xiang, Lujie
Fang, Wentao
Wang, Rui
Preoperative peripheral blood neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratio (PLR) related nomograms predict the survival of patients with limited-stage small-cell lung cancer
title Preoperative peripheral blood neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratio (PLR) related nomograms predict the survival of patients with limited-stage small-cell lung cancer
title_full Preoperative peripheral blood neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratio (PLR) related nomograms predict the survival of patients with limited-stage small-cell lung cancer
title_fullStr Preoperative peripheral blood neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratio (PLR) related nomograms predict the survival of patients with limited-stage small-cell lung cancer
title_full_unstemmed Preoperative peripheral blood neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratio (PLR) related nomograms predict the survival of patients with limited-stage small-cell lung cancer
title_short Preoperative peripheral blood neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratio (PLR) related nomograms predict the survival of patients with limited-stage small-cell lung cancer
title_sort preoperative peripheral blood neutrophil-to-lymphocyte ratios (nlr) and platelet-to-lymphocyte ratio (plr) related nomograms predict the survival of patients with limited-stage small-cell lung cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947425/
https://www.ncbi.nlm.nih.gov/pubmed/33718028
http://dx.doi.org/10.21037/tlcr-20-997
work_keys_str_mv AT chenchunji preoperativeperipheralbloodneutrophiltolymphocyteratiosnlrandplatelettolymphocyteratioplrrelatednomogramspredictthesurvivalofpatientswithlimitedstagesmallcelllungcancer
AT yanghaitang preoperativeperipheralbloodneutrophiltolymphocyteratiosnlrandplatelettolymphocyteratioplrrelatednomogramspredictthesurvivalofpatientswithlimitedstagesmallcelllungcancer
AT caideng preoperativeperipheralbloodneutrophiltolymphocyteratiosnlrandplatelettolymphocyteratioplrrelatednomogramspredictthesurvivalofpatientswithlimitedstagesmallcelllungcancer
AT xianglujie preoperativeperipheralbloodneutrophiltolymphocyteratiosnlrandplatelettolymphocyteratioplrrelatednomogramspredictthesurvivalofpatientswithlimitedstagesmallcelllungcancer
AT fangwentao preoperativeperipheralbloodneutrophiltolymphocyteratiosnlrandplatelettolymphocyteratioplrrelatednomogramspredictthesurvivalofpatientswithlimitedstagesmallcelllungcancer
AT wangrui preoperativeperipheralbloodneutrophiltolymphocyteratiosnlrandplatelettolymphocyteratioplrrelatednomogramspredictthesurvivalofpatientswithlimitedstagesmallcelllungcancer