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Red blood cell distribution width is associated with adverse cardiovascular events after septal myectomy

BACKGROUND: Red blood cell distribution width (RDW) is associated with increased morbidity and mortality in several cardiovascular diseases. However, the prognostic significance of RDW in patients with hypertrophic obstructive cardiomyopathy (HOCM) who underwent septal myectomy remains unclear as no...

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Autores principales: Wang, Shengwei, Song, Changpeng, Cui, Hao, Zhu, Changsheng, Wu, Rong, Huang, Xiaohong, Lai, Yongqiang, Wang, Shuiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947493/
https://www.ncbi.nlm.nih.gov/pubmed/33717531
http://dx.doi.org/10.21037/jtd-20-2528
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author Wang, Shengwei
Song, Changpeng
Cui, Hao
Zhu, Changsheng
Wu, Rong
Huang, Xiaohong
Lai, Yongqiang
Wang, Shuiyun
author_facet Wang, Shengwei
Song, Changpeng
Cui, Hao
Zhu, Changsheng
Wu, Rong
Huang, Xiaohong
Lai, Yongqiang
Wang, Shuiyun
author_sort Wang, Shengwei
collection PubMed
description BACKGROUND: Red blood cell distribution width (RDW) is associated with increased morbidity and mortality in several cardiovascular diseases. However, the prognostic significance of RDW in patients with hypertrophic obstructive cardiomyopathy (HOCM) who underwent septal myectomy remains unclear as no studies have been conducted on this topic. This study aimed to assess the prognostic significance of RDW in these patients. METHODS: A total of 867 adults with HOCM who underwent septal myectomy at Fuwai Hospital from 2011 to 2017 were retrospectively studied. All patients were assessed comprehensively, including their medical history, echocardiograms, and blood test results. RESULTS: The median age of patients was 47.9 [interquartile range (IQR), 37.0–56.0] years and 61.5% of patients were men. During a median follow-up period of 32 (IQR, 17–53) months, 26 patients died and 23 had a cardiovascular death during follow-up. Compared to patients in the lowest RDW quartile, those in the highest quartile had a significantly lower 5-year survival free from all-cause and cardiovascular death (95.9% vs. 87.6%, P<0.001; 95.9% vs. 89.9%, P<0.001). Compared with lower RDW, higher RDW was significantly associated with all-cause and cardiovascular death after adjustment for age, sex, body mass index, and relevant clinical risk factors [per RDW standard deviation (SD) hazard ratio (HR) increase =1.76, 95% confidence interval (CI): 1.54–2.05, P<0.001; per RDW SD HR =1.91, 95% CI: 1.63–2.22, P for trend <0.001]. CONCLUSIONS: Higher RDW is independently associated with all-cause and cardiovascular death in patients with HOCM after septal myectomy. Therefore, this readily available biomarker could be considered as an additive biomarker for risk stratification in these patients.
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spelling pubmed-79474932021-03-12 Red blood cell distribution width is associated with adverse cardiovascular events after septal myectomy Wang, Shengwei Song, Changpeng Cui, Hao Zhu, Changsheng Wu, Rong Huang, Xiaohong Lai, Yongqiang Wang, Shuiyun J Thorac Dis Original Article BACKGROUND: Red blood cell distribution width (RDW) is associated with increased morbidity and mortality in several cardiovascular diseases. However, the prognostic significance of RDW in patients with hypertrophic obstructive cardiomyopathy (HOCM) who underwent septal myectomy remains unclear as no studies have been conducted on this topic. This study aimed to assess the prognostic significance of RDW in these patients. METHODS: A total of 867 adults with HOCM who underwent septal myectomy at Fuwai Hospital from 2011 to 2017 were retrospectively studied. All patients were assessed comprehensively, including their medical history, echocardiograms, and blood test results. RESULTS: The median age of patients was 47.9 [interquartile range (IQR), 37.0–56.0] years and 61.5% of patients were men. During a median follow-up period of 32 (IQR, 17–53) months, 26 patients died and 23 had a cardiovascular death during follow-up. Compared to patients in the lowest RDW quartile, those in the highest quartile had a significantly lower 5-year survival free from all-cause and cardiovascular death (95.9% vs. 87.6%, P<0.001; 95.9% vs. 89.9%, P<0.001). Compared with lower RDW, higher RDW was significantly associated with all-cause and cardiovascular death after adjustment for age, sex, body mass index, and relevant clinical risk factors [per RDW standard deviation (SD) hazard ratio (HR) increase =1.76, 95% confidence interval (CI): 1.54–2.05, P<0.001; per RDW SD HR =1.91, 95% CI: 1.63–2.22, P for trend <0.001]. CONCLUSIONS: Higher RDW is independently associated with all-cause and cardiovascular death in patients with HOCM after septal myectomy. Therefore, this readily available biomarker could be considered as an additive biomarker for risk stratification in these patients. AME Publishing Company 2021-02 /pmc/articles/PMC7947493/ /pubmed/33717531 http://dx.doi.org/10.21037/jtd-20-2528 Text en 2021 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Wang, Shengwei
Song, Changpeng
Cui, Hao
Zhu, Changsheng
Wu, Rong
Huang, Xiaohong
Lai, Yongqiang
Wang, Shuiyun
Red blood cell distribution width is associated with adverse cardiovascular events after septal myectomy
title Red blood cell distribution width is associated with adverse cardiovascular events after septal myectomy
title_full Red blood cell distribution width is associated with adverse cardiovascular events after septal myectomy
title_fullStr Red blood cell distribution width is associated with adverse cardiovascular events after septal myectomy
title_full_unstemmed Red blood cell distribution width is associated with adverse cardiovascular events after septal myectomy
title_short Red blood cell distribution width is associated with adverse cardiovascular events after septal myectomy
title_sort red blood cell distribution width is associated with adverse cardiovascular events after septal myectomy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947493/
https://www.ncbi.nlm.nih.gov/pubmed/33717531
http://dx.doi.org/10.21037/jtd-20-2528
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