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Risk factors of chest wall invasion in non-small cell lung cancer

BACKGROUND: The risk factors for the development of chest wall invasion (CWI) in non-small cell lung cancer (NSCLC) patients are unclear. If the risk factors for the development of CWI can be clarified, surgical treatment might be able to be performed before CWI development, thus improving the progn...

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Autores principales: Motono, Nozomu, Iwai, Shun, Yamagata, Aika, Iijima, Yoshihito, Usuda, Katsuo, Yamada, Sohsuke, Uramoto, Hidetaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947525/
https://www.ncbi.nlm.nih.gov/pubmed/33717555
http://dx.doi.org/10.21037/jtd-20-1722
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author Motono, Nozomu
Iwai, Shun
Yamagata, Aika
Iijima, Yoshihito
Usuda, Katsuo
Yamada, Sohsuke
Uramoto, Hidetaka
author_facet Motono, Nozomu
Iwai, Shun
Yamagata, Aika
Iijima, Yoshihito
Usuda, Katsuo
Yamada, Sohsuke
Uramoto, Hidetaka
author_sort Motono, Nozomu
collection PubMed
description BACKGROUND: The risk factors for the development of chest wall invasion (CWI) in non-small cell lung cancer (NSCLC) patients are unclear. If the risk factors for the development of CWI can be clarified, surgical treatment might be able to be performed before CWI development, thus improving the prognosis. METHODS: In the present study, we enrolled patients who received surgery for NSCLC between January 2008 and December 2019 with available data on the maximum standardized uptake value (SUV(max)) on positron emission tomography (PET) with lesions adjacent to the visceral pleura. Furthermore, the preoperative white blood cell (WBC) count, the preoperative neutrophil-to-lymphocyte ratio (NLR), platelet (Plt) count, levels of lactate dehydrogenase (LDH) and C-reactive protein (CRP) were analyzed as predictive factors of CWI. RESULTS: The relationships between CWI and clinicopathological variables were analyzed, and there were significant differences between patients with and without CWI in the age (P=0.02), maximum tumor diameter on computed tomography (CT) (P<0.01), diameter of tumors adjacent to the visceral pleura (P(max)) (P<0.01), SUV(max) (P<0.01), maximum tumor diameter on a pathological examination (P<0.01), WBC count (P=0.03), Plt count (P=0.04), and levels of LDH (P<0.01) and CRP (P=0.01). Logistic regression analyses of the risk factors related to CWI showed that the age (P=0.02), P(max) (P=0.02), SUV(max) (P=0.01), and LDH (P<0.01) were significant risk factors. CONCLUSIONS: The age, P(max), SUV(max), and LDH levels might be associated with CWI.
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spelling pubmed-79475252021-03-12 Risk factors of chest wall invasion in non-small cell lung cancer Motono, Nozomu Iwai, Shun Yamagata, Aika Iijima, Yoshihito Usuda, Katsuo Yamada, Sohsuke Uramoto, Hidetaka J Thorac Dis Original Article BACKGROUND: The risk factors for the development of chest wall invasion (CWI) in non-small cell lung cancer (NSCLC) patients are unclear. If the risk factors for the development of CWI can be clarified, surgical treatment might be able to be performed before CWI development, thus improving the prognosis. METHODS: In the present study, we enrolled patients who received surgery for NSCLC between January 2008 and December 2019 with available data on the maximum standardized uptake value (SUV(max)) on positron emission tomography (PET) with lesions adjacent to the visceral pleura. Furthermore, the preoperative white blood cell (WBC) count, the preoperative neutrophil-to-lymphocyte ratio (NLR), platelet (Plt) count, levels of lactate dehydrogenase (LDH) and C-reactive protein (CRP) were analyzed as predictive factors of CWI. RESULTS: The relationships between CWI and clinicopathological variables were analyzed, and there were significant differences between patients with and without CWI in the age (P=0.02), maximum tumor diameter on computed tomography (CT) (P<0.01), diameter of tumors adjacent to the visceral pleura (P(max)) (P<0.01), SUV(max) (P<0.01), maximum tumor diameter on a pathological examination (P<0.01), WBC count (P=0.03), Plt count (P=0.04), and levels of LDH (P<0.01) and CRP (P=0.01). Logistic regression analyses of the risk factors related to CWI showed that the age (P=0.02), P(max) (P=0.02), SUV(max) (P=0.01), and LDH (P<0.01) were significant risk factors. CONCLUSIONS: The age, P(max), SUV(max), and LDH levels might be associated with CWI. AME Publishing Company 2021-02 /pmc/articles/PMC7947525/ /pubmed/33717555 http://dx.doi.org/10.21037/jtd-20-1722 Text en 2021 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Motono, Nozomu
Iwai, Shun
Yamagata, Aika
Iijima, Yoshihito
Usuda, Katsuo
Yamada, Sohsuke
Uramoto, Hidetaka
Risk factors of chest wall invasion in non-small cell lung cancer
title Risk factors of chest wall invasion in non-small cell lung cancer
title_full Risk factors of chest wall invasion in non-small cell lung cancer
title_fullStr Risk factors of chest wall invasion in non-small cell lung cancer
title_full_unstemmed Risk factors of chest wall invasion in non-small cell lung cancer
title_short Risk factors of chest wall invasion in non-small cell lung cancer
title_sort risk factors of chest wall invasion in non-small cell lung cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947525/
https://www.ncbi.nlm.nih.gov/pubmed/33717555
http://dx.doi.org/10.21037/jtd-20-1722
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