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Clinicopathological characteristics and prognostic factors of primary pulmonary lymphoma

BACKGROUND: Primary pulmonary lymphoma (PPL) is a rare extranodal lymphoma originating from the lung, accounting for 0.5–1.0% of primary lung malignant tumors. Previous case reports or cohort studies included a limited sample size; therefore, the understanding of the disease remains inadequate, and...

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Autores principales: He, Huayu, Tan, Fengwei, Xue, Qi, Liu, Lei, Peng, Yue, Bai, Guangyu, Zhang, Moyan, Gao, Shugeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947551/
https://www.ncbi.nlm.nih.gov/pubmed/33717584
http://dx.doi.org/10.21037/jtd-20-3159
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author He, Huayu
Tan, Fengwei
Xue, Qi
Liu, Lei
Peng, Yue
Bai, Guangyu
Zhang, Moyan
Gao, Shugeng
author_facet He, Huayu
Tan, Fengwei
Xue, Qi
Liu, Lei
Peng, Yue
Bai, Guangyu
Zhang, Moyan
Gao, Shugeng
author_sort He, Huayu
collection PubMed
description BACKGROUND: Primary pulmonary lymphoma (PPL) is a rare extranodal lymphoma originating from the lung, accounting for 0.5–1.0% of primary lung malignant tumors. Previous case reports or cohort studies included a limited sample size; therefore, the understanding of the disease remains inadequate, and clinical data regarding PPL are limited. METHODS: Patients with PPL diagnosed histologically and radiologically between January 2000 and December 2019 at our center were retrospectively analyzed. RESULTS: In total, 90 consecutive cases were included in this research. Forty-seven (52.2%) patients were female, and the median age was 54 years old. Non-Hodgkin’s lymphoma (PPNHL) was the most common type of PPL (71/90, 78.9%), and mucosa-associated lymphoid tissue (MALT) lymphoma was the most common pathological subtype of PPNHL (56.3%) followed by diffuse large B-cell lymphoma (DLBCL) (32.4%). Thirty-nine (43.3%) patients underwent surgical treatment, and the others received chemotherapy alone or combined with radiotherapy. The estimated 5-year overall survival (OS) rates of MALT lymphoma and non-MALT lymphoma were 68.9% and 65.9%, respectively. Univariate analysis of PPL showed that clinicopathological features that significantly correlated with worse OS were age over 60 years (P=0.006<0.05), elevated LDH (P=0.029<0.05) and β2-MG (P=0.048<0.05) levels, clinical stage II2E and greater (P=0.015<0.05), and nonsurgical treatment (P=0.046<0.05). Age (P=0.013<0.05) was an independent prognostic factor for the 5-year OS of patients through multivariate analysis. CONCLUSIONS: Age over 60 years old, elevated LDH and β2-MG levels, clinical stage II2E disease or higher, and nonsurgical treatment were associated with poor prognosis in patients with PPL. Age can be used as a potential independent prognostic factor for PPL.
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spelling pubmed-79475512021-03-12 Clinicopathological characteristics and prognostic factors of primary pulmonary lymphoma He, Huayu Tan, Fengwei Xue, Qi Liu, Lei Peng, Yue Bai, Guangyu Zhang, Moyan Gao, Shugeng J Thorac Dis Original Article BACKGROUND: Primary pulmonary lymphoma (PPL) is a rare extranodal lymphoma originating from the lung, accounting for 0.5–1.0% of primary lung malignant tumors. Previous case reports or cohort studies included a limited sample size; therefore, the understanding of the disease remains inadequate, and clinical data regarding PPL are limited. METHODS: Patients with PPL diagnosed histologically and radiologically between January 2000 and December 2019 at our center were retrospectively analyzed. RESULTS: In total, 90 consecutive cases were included in this research. Forty-seven (52.2%) patients were female, and the median age was 54 years old. Non-Hodgkin’s lymphoma (PPNHL) was the most common type of PPL (71/90, 78.9%), and mucosa-associated lymphoid tissue (MALT) lymphoma was the most common pathological subtype of PPNHL (56.3%) followed by diffuse large B-cell lymphoma (DLBCL) (32.4%). Thirty-nine (43.3%) patients underwent surgical treatment, and the others received chemotherapy alone or combined with radiotherapy. The estimated 5-year overall survival (OS) rates of MALT lymphoma and non-MALT lymphoma were 68.9% and 65.9%, respectively. Univariate analysis of PPL showed that clinicopathological features that significantly correlated with worse OS were age over 60 years (P=0.006<0.05), elevated LDH (P=0.029<0.05) and β2-MG (P=0.048<0.05) levels, clinical stage II2E and greater (P=0.015<0.05), and nonsurgical treatment (P=0.046<0.05). Age (P=0.013<0.05) was an independent prognostic factor for the 5-year OS of patients through multivariate analysis. CONCLUSIONS: Age over 60 years old, elevated LDH and β2-MG levels, clinical stage II2E disease or higher, and nonsurgical treatment were associated with poor prognosis in patients with PPL. Age can be used as a potential independent prognostic factor for PPL. AME Publishing Company 2021-02 /pmc/articles/PMC7947551/ /pubmed/33717584 http://dx.doi.org/10.21037/jtd-20-3159 Text en 2021 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
He, Huayu
Tan, Fengwei
Xue, Qi
Liu, Lei
Peng, Yue
Bai, Guangyu
Zhang, Moyan
Gao, Shugeng
Clinicopathological characteristics and prognostic factors of primary pulmonary lymphoma
title Clinicopathological characteristics and prognostic factors of primary pulmonary lymphoma
title_full Clinicopathological characteristics and prognostic factors of primary pulmonary lymphoma
title_fullStr Clinicopathological characteristics and prognostic factors of primary pulmonary lymphoma
title_full_unstemmed Clinicopathological characteristics and prognostic factors of primary pulmonary lymphoma
title_short Clinicopathological characteristics and prognostic factors of primary pulmonary lymphoma
title_sort clinicopathological characteristics and prognostic factors of primary pulmonary lymphoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947551/
https://www.ncbi.nlm.nih.gov/pubmed/33717584
http://dx.doi.org/10.21037/jtd-20-3159
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