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Passive Immunization With a Novel Monoclonal Anti-PrP Antibody TW1 in an Alzheimer’s Mouse Model With Tau Pathology

Neurofibrillary tangles (NFTs) are a major pathologic hallmark of Alzheimer’s disease (AD). Several studies have shown that amyloid β oligomers (Aβo) and tau oligomers mediate their toxicity, in part, via binding to cellular prion protein (PrP(C)) and that some anti-PrP antibodies can block this int...

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Detalles Bibliográficos
Autores principales:	Boutajangout, Allal, Zhang, Wei, Kim, Justin, Abdali, Wed Ali, Prelli, Frances, Wisniewski, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947695/ https://www.ncbi.nlm.nih.gov/pubmed/33716717 http://dx.doi.org/10.3389/fnagi.2021.640677

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