The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy

Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) infection. It is also characterized by heavy infiltration with non-malignant leucocytes. The EBV-encoded latent membrane protein 1 (LMP1) is believed to play an important role in NPC pathogenesis by virtue of its abil...

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Autores principales: Lo, Angela Kwok-Fung, Dawson, Christopher W., Lung, Hong Lok, Wong, Ka-Leung, Young, Lawrence S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947715/
https://www.ncbi.nlm.nih.gov/pubmed/33718235
http://dx.doi.org/10.3389/fonc.2021.640207
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author Lo, Angela Kwok-Fung
Dawson, Christopher W.
Lung, Hong Lok
Wong, Ka-Leung
Young, Lawrence S.
author_facet Lo, Angela Kwok-Fung
Dawson, Christopher W.
Lung, Hong Lok
Wong, Ka-Leung
Young, Lawrence S.
author_sort Lo, Angela Kwok-Fung
collection PubMed
description Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) infection. It is also characterized by heavy infiltration with non-malignant leucocytes. The EBV-encoded latent membrane protein 1 (LMP1) is believed to play an important role in NPC pathogenesis by virtue of its ability to activate multiple cell signaling pathways which collectively promote cell proliferation and survival, angiogenesis, invasiveness, and aerobic glycolysis. LMP1 also affects cell-cell interactions, antigen presentation, and cytokine and chemokine production. Here, we discuss how LMP1 modulates local immune responses that contribute to the establishment of the NPC tumor microenvironment. We also discuss strategies for targeting the LMP1 protein as a novel therapy for EBV-driven malignancies.
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spelling pubmed-79477152021-03-12 The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy Lo, Angela Kwok-Fung Dawson, Christopher W. Lung, Hong Lok Wong, Ka-Leung Young, Lawrence S. Front Oncol Oncology Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) infection. It is also characterized by heavy infiltration with non-malignant leucocytes. The EBV-encoded latent membrane protein 1 (LMP1) is believed to play an important role in NPC pathogenesis by virtue of its ability to activate multiple cell signaling pathways which collectively promote cell proliferation and survival, angiogenesis, invasiveness, and aerobic glycolysis. LMP1 also affects cell-cell interactions, antigen presentation, and cytokine and chemokine production. Here, we discuss how LMP1 modulates local immune responses that contribute to the establishment of the NPC tumor microenvironment. We also discuss strategies for targeting the LMP1 protein as a novel therapy for EBV-driven malignancies. Frontiers Media S.A. 2021-02-25 /pmc/articles/PMC7947715/ /pubmed/33718235 http://dx.doi.org/10.3389/fonc.2021.640207 Text en Copyright © 2021 Lo, Dawson, Lung, Wong and Young http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lo, Angela Kwok-Fung
Dawson, Christopher W.
Lung, Hong Lok
Wong, Ka-Leung
Young, Lawrence S.
The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy
title The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy
title_full The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy
title_fullStr The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy
title_full_unstemmed The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy
title_short The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy
title_sort role of ebv-encoded lmp1 in the npc tumor microenvironment: from function to therapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947715/
https://www.ncbi.nlm.nih.gov/pubmed/33718235
http://dx.doi.org/10.3389/fonc.2021.640207
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