Suboptimal Global Transcriptional Response Increases the Harmful Effects of Loss-of-Function Mutations

The fitness impact of loss-of-function mutations is generally assumed to reflect the loss of specific molecular functions associated with the perturbed gene. Here, we propose that rewiring of the transcriptome upon deleterious gene inactivation is frequently nonspecific and mimics stereotypic respon...

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Detalles Bibliográficos
Autores principales: Kovács, Károly, Farkas, Zoltán, Bajić, Djordje, Kalapis, Dorottya, Daraba, Andreea, Almási, Karola, Kintses, Bálint, Bódi, Zoltán, Notebaart, Richard A, Poyatos, Juan F, Kemmeren, Patrick, Holstege, Frank C P, Pál, Csaba, Papp, Balázs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947755/
https://www.ncbi.nlm.nih.gov/pubmed/33306797
http://dx.doi.org/10.1093/molbev/msaa280

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