Claudin-4 Immunoexpression in Urothelial Carcinomas

The involvement of claudins in urothelial carcinogenesis is controversial. In this study, we analyzed Claudin-4 immunoexpression in 50 cases of bladder urothelial carcinomas depending on the main prognostic parameters of the lesions represented by the tumor grade and tumor extension. Claudin-4 immun...

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Detalles Bibliográficos
Autores principales: SĂNDULESCU, ANDREI ŞTEFAN, STEPAN, ALEX EMILIAN, MĂRGĂRITESCU, CLAUDIU, BADIU, ANNE MARIE, MATEI, MARIUS, SIMIONESCU, CRISTIANA EUGENIA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948025/
https://www.ncbi.nlm.nih.gov/pubmed/33717512
http://dx.doi.org/10.12865/CHSJ.46.04.08
Descripción
Sumario:The involvement of claudins in urothelial carcinogenesis is controversial. In this study, we analyzed Claudin-4 immunoexpression in 50 cases of bladder urothelial carcinomas depending on the main prognostic parameters of the lesions represented by the tumor grade and tumor extension. Claudin-4 immunoexpression scores were significantly higher in high-grade urothelial carcinomas and in tumors with invasion in muscularis propria. The results obtained indicate the involvement of Claudin-4 in the progression of urothelial bladder carcinomas.

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