Inhibition of HDAC4 by GSK3β leads to downregulation of KLF5 and ASK1 and prevents the progression of intravertebral disc degeneration

BACKGROUND: Intervertebral disc degeneration (IDD) is a major cause of lower back pain. This study aimed at exploring the effects of histone deacetylase 4 (HDAC4) and its upstream and downstream signaling molecules on IDD development. METHODS: A murine IDD model was established by inducing a needle...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Lin, Gong, Dongping, Liang, Loufeng, Liang, Anwei, Liang, Huaxin, Xu, Xiayi, Teng, Hongli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948391/
https://www.ncbi.nlm.nih.gov/pubmed/33691773
http://dx.doi.org/10.1186/s13148-021-01005-9

Ejemplares similares

Ejemplares similares