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MEK1/2 activity modulates TREM2 cell surface recruitment

Rare sequence variants in the microglial cell surface receptor TREM2 have been shown to increase the risk for Alzheimer’s disease (AD). Disease-linked TREM2 mutations seem to confer a partial loss of function, and increasing TREM2 cell surface expression and thereby its function(s) might have therap...

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Detalles Bibliográficos
Autores principales:	Schapansky, Jason, Grinberg, Yelena Y., Osiecki, David M., Freeman, Emily A., Walker, Stephen G., Karran, Eric, Gopalakrishnan, Sujatha M., Talanian, Robert V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948395/ https://www.ncbi.nlm.nih.gov/pubmed/33839686 http://dx.doi.org/10.1074/jbc.RA120.014352

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