Cargando…

Cholesterol stimulates the cellular uptake of L-carnitine by the carnitine/organic cation transporter novel 2 (OCTN2)

The carnitine/organic cation transporter novel 2 (OCTN2) is responsible for the cellular uptake of carnitine in most tissues. Being a transmembrane protein OCTN2 must interact with the surrounding lipid microenvironment to function. Among the main lipid species that constitute eukaryotic cells, chol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Lu, Gui, Ting, Console, Lara, Scalise, Mariafrancesca, Indiveri, Cesare, Hausler, Stephanie, Kullak-Ublick, Gerd A., Gai, Zhibo, Visentin, Michele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948396/ https://www.ncbi.nlm.nih.gov/pubmed/33334877 http://dx.doi.org/10.1074/jbc.RA120.015175

Ejemplares similares

Characterization of Exosomal SLC22A5 (OCTN2) carnitine transporter
por: Console, Lara, et al.
Publicado: (2018)

Effect of Cholesterol on the Organic Cation Transporter OCTN1 (SLC22A4)
por: Pochini, Lorena, et al.
Publicado: (2020)

Carnitine Traffic in Cells. Link With Cancer
por: Console, Lara, et al.
Publicado: (2020)

OCTN1: A Widely Studied but Still Enigmatic Organic Cation Transporter Linked to Human Pathology and Drug Interactions
por: Pochini, Lorena, et al.
Publicado: (2022)

Inhibition of the Mitochondrial Carnitine/Acylcarnitine Carrier by Itaconate through Irreversible Binding to Cysteine 136: Possible Pathophysiological Implications
por: Giangregorio, Nicola, et al.
Publicado: (2023)

The Role of the Carnitine/Organic Cation Transporter Novel 2 in the Clinical Outcome of Patients With Locally Advanced Esophageal Carcinoma Treated With Oxaliplatin
por: Sun, Dongfeng, et al.
Publicado: (2021)

Carnitine transporter OCTN2 and carnitine uptake in bovine kidney cells is regulated by peroxisome proliferator-activated receptor β/δ
por: Zhou, Xiaodan, et al.
Publicado: (2014)

Residual OCTN2 transporter activity, carnitine levels and symptoms correlate in patients with primary carnitine deficiency
por: Rasmussen, Jan, et al.
Publicado: (2014)

Organic Cation Transporters in Human Physiology, Pharmacology, and Toxicology
por: Samodelov, Sophia L., et al.
Publicado: (2020)

The Mitochondrial Carnitine Acyl-carnitine Carrier (SLC25A20): Molecular Mechanisms of Transport, Role in Redox Sensing and Interaction with Drugs
por: Tonazzi, Annamaria, et al.
Publicado: (2021)

Strategies of Bacterial Over Expression of Membrane Transporters Relevant in Human Health: The Successful Case of the Three Members of OCTN Subfamily
por: Indiveri, Cesare, et al.
Publicado: (2012)

Overproduction, Purification, and Stability of the Functionally Active Human Carnitine Acetyl Transferase
por: Giudice, Deborah, et al.
Publicado: (2022)

Different Involvement of Promoter Methylation in the Expression of Organic Cation/Carnitine Transporter 2 (OCTN2) in Cancer Cell Lines
por: Qu, Qiang, et al.
Publicado: (2013)

Organic cation/carnitine transporter (OCTN2) interaction proteome in rat astrocytes: Role of phosphatase PP2A
por: Nalecz, Katarzyna, et al.
Publicado: (2015)

Renal Glycosuria as a Novel Early Sign of Colistin-Induced Kidney Damage in Mice
por: Samodelov, Sophia L., et al.
Publicado: (2019)

OCTN2-Mediated Acetyl-l-Carnitine Transport in Human Pulmonary Epithelial Cells In Vitro
por: Salomon, Johanna J., et al.
Publicado: (2019)

The Role of NF-kB in the Downregulation of Organic Cation Transporter 2 Expression and Renal Cation Secretion in Kidney Disease
por: Han, Chao, et al.
Publicado: (2022)

The Role of Mitochondria in Drug-Induced Kidney Injury
por: Gai, Zhibo, et al.
Publicado: (2020)

Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men
por: Meisel, Peter, et al.
Publicado: (2020)

Interaction of Cholesterol With the Human SLC1A5 (ASCT2): Insights Into Structure/Function Relationships
por: Scalise, Mariafrancesca, et al.
Publicado: (2019)

Caveolin-1 - A Novel Interacting Partner of Organic Cation/Carnitine Transporter (Octn2): Effect of Protein Kinase C on This Interaction in Rat Astrocytes
por: Czeredys, Magdalena, et al.
Publicado: (2013)

Correction to: Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men
por: Meisel, Peter, et al.
Publicado: (2021)

Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency
por: Koleske, Megan L., et al.
Publicado: (2022)

Characterization of ligand-induced thermal stability of the human organic cation transporter 2 (OCT2)
por: Maane, Max, et al.
Publicado: (2023)

Molecular Mechanisms of Colistin-Induced Nephrotoxicity
por: Gai, Zhibo, et al.
Publicado: (2019)

Renal Reabsorption of Folates: Pharmacological and Toxicological Snapshots
por: Samodelov, Sophia L, et al.
Publicado: (2019)

Effect of Copper on the Mitochondrial Carnitine/Acylcarnitine Carrier Via Interaction with Cys136 and Cys155. Possible Implications in Pathophysiology
por: Giangregorio, Nicola, et al.
Publicado: (2020)

The Human SLC1A5 (ASCT2) Amino Acid Transporter: From Function to Structure and Role in Cell Biology
por: Scalise, Mariafrancesca, et al.
Publicado: (2018)

Cysteine 467 of the ASCT2 Amino Acid Transporter Is a Molecular Determinant of the Antiport Mechanism
por: Scalise, Mariafrancesca, et al.
Publicado: (2022)

SLC22A5 (OCTN2) Carnitine Transporter—Indispensable for Cell Metabolism, a Jekyll and Hyde of Human Cancer
por: Juraszek, Barbara, et al.
Publicado: (2019)

Dual targeting of l-carnitine-conjugated nanoparticles to OCTN2 and ATB(0,+) to deliver chemotherapeutic agents for colon cancer therapy
por: Kou, Longfa, et al.
Publicado: (2017)

Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth
por: Scalise, Mariafrancesca, et al.
Publicado: (2017)

The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health
por: Scalise, Mariafrancesca, et al.
Publicado: (2018)

Chemical Targeting of Membrane Transporters: Insights into Structure/Function Relationships
por: Scalise, Mariafrancesca, et al.
Publicado: (2020)

Glutamine transporters as pharmacological targets: From function to drug design
por: Scalise, Mariafrancesca, et al.
Publicado: (2020)

Amino Acids Transport and Metabolism 2.0
por: Scalise, Mariafrancesca, et al.
Publicado: (2020)

Lipid Accumulation and Chronic Kidney Disease
por: Gai, Zhibo, et al.
Publicado: (2019)

Regulatory Aspects of the Vacuolar CAT2 Arginine Transporter of S. lycopersicum: Role of Osmotic Pressure and Cations
por: Cosco, Jessica, et al.
Publicado: (2019)

Repurposing Nimesulide, a Potent Inhibitor of the B0AT1 Subunit of the SARS-CoV-2 Receptor, as a Therapeutic Adjuvant of COVID-19
por: Scalise, Mariafrancesca, et al.
Publicado: (2020)

Genes involved in carnitine synthesis and carnitine uptake are up-regulated in the liver of sows during lactation
por: Rosenbaum, Susann, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_p2va9t8dlsfp2b441m7bnlchnr