A novel soluble complement receptor 1 fragment with enhanced therapeutic potential

Human complement receptor 1 (HuCR1) is a pivotal regulator of complement activity, acting on all three complement pathways as a membrane-bound receptor of C3b/C4b, C3/C5 convertase decay accelerator, and cofactor for factor I-mediated cleavage of C3b and C4b. In this study, we sought to identify a m...

Descripción completa

Detalles Bibliográficos
Autores principales: Wymann, Sandra, Dai, Yun, Nair, Anup G., Cao, Helen, Powers, Glenn A., Schnell, Anna, Martin-Roussety, Genevieve, Leong, David, Simmonds, Jason, Lieu, Kim G., de Souza, Mitchell J., Mischnik, Marcel, Taylor, Shirley, Ow, Saw Yen, Spycher, Martin, Butcher, Rebecca E., Pearse, Martin, Zuercher, Adrian W., Baz Morelli, Adriana, Panousis, Con, Wilson, Michael J., Rowe, Tony, Hardy, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948397/
https://www.ncbi.nlm.nih.gov/pubmed/33334893
http://dx.doi.org/10.1074/jbc.RA120.016127

Ejemplares similares

Ejemplares similares