SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1

Inducible degrader of the low-density lipoprotein receptor (IDOL) is an E3 ubiquitin ligase mediating degradation of low-density lipoprotein (LDL) receptor (LDLR). IDOL also controls its own stability through autoubiquitination, primarily at lysine 293. Whether IDOL may undergo other forms of posttr...

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Detalles Bibliográficos
Autores principales: Wang, Ju-Qiong, Lin, Zi-Cun, Li, Liang-Liang, Zhang, Shao-Fang, Li, Wei-Hui, Liu, Wei, Song, Bao-Liang, Luo, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948399/
https://www.ncbi.nlm.nih.gov/pubmed/33154164
http://dx.doi.org/10.1074/jbc.RA120.015420

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