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Combinatorial CAR design improves target restriction

CAR T cells targeting the B lymphocyte antigen CD19 have led to remarkable clinical results in B cell leukemia and lymphoma but eliminate all B lineage cells, leading to increased susceptibility to severe infections. As malignant B cells will express either immunoglobulin (Ig) light chain κ or λ, we...

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Detalles Bibliográficos
Autores principales:	Köksal, Hakan, Dillard, Pierre, Juzeniene, Asta, Kvalheim, Gunnar, Smeland, Erlend B., Myklebust, June H., Inderberg, Else Marit, Wälchli, Sébastien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948400/ https://www.ncbi.nlm.nih.gov/pubmed/33234592 http://dx.doi.org/10.1074/jbc.RA120.016234

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