Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling

Uveal melanoma is the most common eye cancer in adults and is clinically and genetically distinct from skin cutaneous melanoma. In a subset of cases, the oncogenic driver is an activating mutation in CYSLTR2, the gene encoding the G protein–coupled receptor cysteinyl-leukotriene receptor 2 (CysLTR2)...

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Detalles Bibliográficos
Autores principales: Ceraudo, Emilie, Horioka, Mizuho, Mattheisen, Jordan M., Hitchman, Tyler D., Moore, Amanda R., Kazmi, Manija A., Chi, Ping, Chen, Yu, Sakmar, Thomas P., Huber, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948404/
https://www.ncbi.nlm.nih.gov/pubmed/33288675
http://dx.doi.org/10.1074/jbc.RA120.015352

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